Product Name
14-3-3-pan, Polyclonal Antibody
Full Product Name
Acetyl-14-3-3-pan (Lys51/49) Polyclonal Antibody
Product Gene Name
anti-14-3-3-pan antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P31946
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/mL (lot specific)
Immunogen
Synthesized peptide derived from human 14-3-3-pan around the acetylation site of K51.
Buffer
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-14-3-3-pan antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-14-3-3-pan antibody
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis.
Product Categories/Family for anti-14-3-3-pan antibody
Acetyl/Phospho/Methyl Antibody
Applications Tested/Suitable for anti-14-3-3-pan antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-14-3-3-pan antibody
WB: 1:500-1:2000
ELISA: 1:10000
Western Blot (WB) of anti-14-3-3-pan antibody
Western Blot analysis of Mouse spleen using 14-3-3-pan (Acetyl Lys51/49) Polyclonal Antibody at dilution of 1:500.
NCBI/Uniprot data below describe general gene information for 14-3-3-pan. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003395.1
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NCBI GenBank Nucleotide #
NM_003404.4
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UniProt Primary Accession #
P31946
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UniProt Secondary Accession #
A8K9K2; E1P616[Other Products]
UniProt Related Accession #
P31946[Other Products]
NCBI Official Full Name
14-3-3 protein beta/alpha
NCBI Official Synonym Full Names
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
NCBI Official Symbol
YWHAB??[Similar Products]
NCBI Official Synonym Symbols
HS1; GW128; YWHAA; KCIP-1; HEL-S-1
??[Similar Products]
NCBI Protein Information
14-3-3 protein beta/alpha
UniProt Protein Name
14-3-3 protein beta/alpha
UniProt Synonym Protein Names
Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1
UniProt Gene Name
YWHAB??[Similar Products]
UniProt Synonym Gene Names
KCIP-1??[Similar Products]
NCBI Summary for 14-3-3-pan
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for 14-3-3-pan
14-3-3 beta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 20q13.12
Cellular Component: cytoplasm; cytoplasmic vesicle membrane; cytosol; extracellular exosome; focal adhesion; melanosome; membrane; mitochondrion; nucleus; perinuclear region of cytoplasm; protein complex; transcriptional repressor complex
Molecular Function: cadherin binding; enzyme binding; histone deacetylase binding; identical protein binding; phosphoprotein binding; phosphoserine binding; protein binding; protein C-terminus binding; protein complex binding; protein domain specific binding; transcription corepressor activity
Biological Process: cytoplasmic sequestering of protein; MAPK cascade; negative regulation of G-protein coupled receptor protein signaling pathway; negative regulation of protein dephosphorylation; negative regulation of transcription, DNA-dependent; positive regulation of catalytic activity; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; protein heterooligomerization; protein targeting; regulation of mRNA stability; viral process
Research Articles on 14-3-3-pan
1. Data show that 14-3-3beta protein augmented the expression of matrix metalloproteinasea MMP2 and MMP9 through PI3 kinase/Akt protein/NF-kappaappa B pathway, thereby enhancing the invasiveness of hepatocellular carcinoma (HCC) cells.
Precautions
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Disclaimer
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