Protein kinase C inhibitor protein 1 protein; Tyrosine 3 Monooxygenase/Tryptophan 5 Monooxygenase Activation Protein Beta Polypeptide.; Brain protein 14 3 3 beta isoform protein; HS1 protein; 14-3-3 beta; 14-3-3 beta protein; beta polypeptide protein; KCIP-1 protein; GW 128 protein; Protein 1054 protein; YWHAB protein; 14.3.3 beta; HS 1 protein; 14/3/3 beta protein; beta polypeptide 14 3 3 protein beta/alpha protein; GW128 protein; KCIP 1 protein; Tyrosine 3-monocxygenase/tryptopan 5-monooxygenase activation protein protein; KCIP1 protein; 14/3/3 beta

For Research Use Only. Not for use in diagnostic procedures.

Human

> 90% pure

Supplied as a liquid in 20mM Tris, pH 8.0, containing 1mM EDTA, and 50mM NaCl.

1 mg/ml (lot specific)

Store at 4 degree C for short term storage (1/2 weeks). Aliquot and store at -20 degree C or - 70 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Small volumes of 14.3.3 beta recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Purified recombinant Human 14.3.3 beta protein

Signal Transduction

SDS-PAGE

Figure annotation denotes ug of protein loaded and % gel used.

28 kDa (246 aa), confirmed by MALDI-TOF.

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

14-3-3 protein beta/alpha

14-3-3 protein beta/alpha

KCIP-1??[Similar Products]

1433B_HUMAN

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

14-3-3 beta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 20q13.1

Cellular Component: cytoplasmic vesicle membrane; focal adhesion; membrane; transcriptional repressor complex; perinuclear region of cytoplasm; cytoplasm; melanosome; nucleus; cytosol

Molecular Function: protein C-terminus binding; protein domain specific binding; protein binding; enzyme binding; histone deacetylase binding; protein complex binding; phosphoprotein binding; transcription corepressor activity; phosphoserine binding

Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of catalytic activity; negative regulation of protein amino acid dephosphorylation; axon guidance; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; activation of MAPKK activity; protein heterooligomerization; apoptosis; MAPKKK cascade; small GTPase mediated signal transduction; Ras protein signal transduction; cytoplasmic sequestering of protein; insulin receptor signaling pathway; innate immune response; gene expression; negative regulation of transcription, DNA-dependent; vascular endothelial growth factor receptor signaling pathway; protein targeting

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