Product Name
RAB40AL, Polyclonal Antibody
Full Product Name
RAB40AL Antibody (N-term)
Product Synonym Names
Ras-related protein Rab-40A-like; Ras-like GTPase; RAB40AL; RLGP
Product Gene Name
anti-RAB40AL antibody
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Antibody/Peptide Pairs
RAB40AL peptide (MBS9228545) is used for blocking the activity of RAB40AL antibody (MBS9208783)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
7-36
3D Structure
ModBase 3D Structure for P0C0E4
Specificity
This RAB40AL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-36 amino acids from the N-terminal region of human RAB40AL.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.45 (lot specific)
Antigen Type
Synthetic Peptide
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-RAB40AL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RAB40AL antibody
This gene encodes a member of the Rab40 subfamily of Rab small GTP-binding proteins that contains a C-terminal suppressors of cytokine signaling box. Disruptions in this gene are associated with Duchenne muscular dystrophy.
Applications Tested/Suitable for anti-RAB40AL antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-RAB40AL antibody
WB~~1:1000
Western Blot (WB) of anti-RAB40AL antibody
Western blot analysis of RAB40AL Antibdy (N-term) Pab pre-incubated without(lane 1) and with(lane 2) blocking peptide in ZR-75-1 cell line lysate. RAB40AL Antibdy (N-term) (arrow) was detected using the purified Pab.
Immunohistochemistry (IHC) of anti-RAB40AL antibody
RAB40AL Antibdy (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RAB40AL Antibdy (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
NCBI/Uniprot data below describe general gene information for RAB40AL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001027004.1
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NCBI GenBank Nucleotide #
NM_001031834.1
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UniProt Primary Accession #
P0C0E4
[Other Products]
UniProt Secondary Accession #
Q495H3[Other Products]
UniProt Related Accession #
P0C0E4[Other Products]
NCBI Official Full Name
ras-related protein Rab-40A-like
NCBI Official Synonym Full Names
RAB40A, member RAS oncogene family-like
NCBI Official Symbol
RAB40AL??[Similar Products]
NCBI Official Synonym Symbols
RAR2; RLGP; MRXSMP
??[Similar Products]
NCBI Protein Information
ras-related protein Rab-40A-like
UniProt Protein Name
Ras-related protein Rab-40A-like
UniProt Synonym Protein Names
Ras-like GTPase
Protein Family
Ras-related protein
UniProt Gene Name
RAB40AL??[Similar Products]
UniProt Synonym Gene Names
RLGP??[Similar Products]
UniProt Entry Name
RB40L_HUMAN
NCBI Summary for RAB40AL
This gene encodes a member of the Rab40 subfamily of Rab small GTP-binding proteins that contains a C-terminal suppressors of cytokine signaling box. Disruptions in this gene are associated with Duchenne muscular dystrophy. [provided by RefSeq, Apr 2010]
UniProt Comments for RAB40AL
RAB40AL: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Belongs to the small GTPase superfamily. Rab family.
Protein type: G protein; G protein, monomeric; Ubiquitin conjugating system; G protein, monomeric, Rab
Chromosomal Location of Human Ortholog: Xq22.2
Cellular Component: mitochondrion; cytoplasm; plasma membrane; endosome membrane
Molecular Function: GTPase activity; GDP binding; GTP binding
Biological Process: regulation of exocytosis; intracellular protein transport; protein secretion; protein ubiquitination; Rab protein signal transduction; vesicle docking during exocytosis
Disease: Mental Retardation, X-linked, Syndromic, Martin-probst Type
Product References and Citations for anti-RAB40AL antibody
Saito-Ohara, F., et al. Am. J. Hum. Genet. 71(3):637-645(2002) Kile, B.T., et al. Trends Biochem. Sci. 27(5):235-241(2002)
Research Articles on RAB40AL
1. Data question the role of RAB40AL mutation as a disease-causing change and the involvement of RAB40AL in Martin-Probst syndrome.
Precautions
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