Product Name
PCDH15, Polyclonal Antibody
Product Synonym Names
CDHR15; DFNB23; USH1F
Product Gene Name
anti-PCDH15 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96QU1
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human PCDH15
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-PCDH15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PCDH15 antibody
This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur.
Applications Tested/Suitable for anti-PCDH15 antibody
Western Blot (WB)
Application Notes for anti-PCDH15 antibody
WB: 1:500-1:2000
NCBI/Uniprot data below describe general gene information for PCDH15. It may not necessarily be applicable to this product.
NCBI Accession #
NP_149045.3
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NCBI GenBank Nucleotide #
NM_033056.3
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UniProt Primary Accession #
Q96QU1
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UniProt Secondary Accession #
Q5VY38; Q5VY39; Q6TRH8; Q8NDB9; Q96QT8; A6NL19; C6ZEF5; C6ZEF6; C6ZEF7[Other Products]
UniProt Related Accession #
Q96QU1[Other Products]
NCBI Official Full Name
protocadherin-15 isoform CD1-4
NCBI Official Synonym Full Names
protocadherin related 15
NCBI Official Symbol
PCDH15??[Similar Products]
NCBI Official Synonym Symbols
USH1F; CDHR15; DFNB23
??[Similar Products]
NCBI Protein Information
protocadherin-15
UniProt Protein Name
Protocadherin-15
Protein Family
Protocadherin
UniProt Gene Name
PCDH15??[Similar Products]
UniProt Synonym Gene Names
USH1F??[Similar Products]
NCBI Summary for PCDH15
This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur. [provided by RefSeq, Dec 2008]
UniProt Comments for PCDH15
Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.
Research Articles on PCDH15
1. We found a remarkable genetic heterogeneity in the studied families with USH1 with a variety of mutations, among which three were novel. These novel mutations will be included in the NADf mutation screening chip that will allow a higher diagnosis efficiency of this extremely genetically heterogeneous disease.
Precautions
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Disclaimer
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