Product Name
Protocadherin-15 (PCDH15), Recombinant Protein
Full Product Name
Recombinant Human Protocadherin-15 (PCDH15) , partial
Product Gene Name
PCDH15 recombinant protein
[Similar Products]
Product Synonym Gene Name
PCDH15[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96QU1
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of PCDH15 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PCDH15 recombinant protein
This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur.
NCBI/Uniprot data below describe general gene information for PCDH15. It may not necessarily be applicable to this product.
NCBI Accession #
NP_149045.3
[Other Products]
NCBI GenBank Nucleotide #
NM_033056.3
[Other Products]
UniProt Primary Accession #
Q96QU1
[Other Products]
UniProt Secondary Accession #
Q5VY38; Q5VY39; Q6TRH8; Q8NDB9; Q96QT8; A6NL19; C6ZEF5; C6ZEF6; C6ZEF7[Other Products]
UniProt Related Accession #
Q96QU1[Other Products]
Molecular Weight
185,964 Da
NCBI Official Full Name
protocadherin-15 isoform CD1-4
NCBI Official Synonym Full Names
protocadherin related 15
NCBI Official Symbol
PCDH15??[Similar Products]
NCBI Official Synonym Symbols
USH1F; CDHR15; DFNB23
??[Similar Products]
NCBI Protein Information
protocadherin-15
UniProt Protein Name
Protocadherin-15
Protein Family
Protocadherin
UniProt Gene Name
PCDH15??[Similar Products]
UniProt Synonym Gene Names
USH1F??[Similar Products]
NCBI Summary for PCDH15
This gene is a member of the cadherin superfamily. Family members encode integral membrane proteins that mediate calcium-dependent cell-cell adhesion. It plays an essential role in maintenance of normal retinal and cochlear function. Mutations in this gene result in hearing loss and Usher Syndrome Type IF (USH1F). Extensive alternative splicing resulting in multiple isoforms has been observed in the mouse ortholog. Similar alternatively spliced transcripts are inferred to occur in human, and additional variants are likely to occur. [provided by RefSeq, Dec 2008]
UniProt Comments for PCDH15
Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function.
Research Articles on PCDH15
1. We found a remarkable genetic heterogeneity in the studied families with USH1 with a variety of mutations, among which three were novel. These novel mutations will be included in the NADf mutation screening chip that will allow a higher diagnosis efficiency of this extremely genetically heterogeneous disease.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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