NFE1B; Endothelial transcription factor GATA-2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

200ug/ml (lot specific)

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.

Small volumes of anti-GATA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunohistochemistry (IHC)

49,106 Da

GATA binding protein 2

endothelial transcription factor GATA-2

Endothelial transcription factor GATA-2

This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

GATA2: Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. Endothelial cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: nucleoplasm; nucleus; transcription factor complex

Molecular Function: chromatin binding; DNA binding transcription factor activity; protein binding; transcription factor binding; zinc ion binding

Biological Process: blood coagulation; cell differentiation in hindbrain; cell fate determination; cell maturation; central nervous system neuron development; cochlea development; commitment of a neuronal cell to a specific type of neuron in the forebrain; elevation of cytosolic calcium ion concentration; embryonic placenta development; homeostasis of number of cells within a tissue; inner ear morphogenesis; negative regulation of endothelial cell apoptotic process; negative regulation of fat cell differentiation; negative regulation of fat cell proliferation; negative regulation of macrophage differentiation; negative regulation of neural precursor cell proliferation; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter; neuron migration; phagocytosis; pituitary gland development; positive regulation of angiogenesis; positive regulation of erythrocyte differentiation; positive regulation of mast cell degranulation; positive regulation of megakaryocyte differentiation; positive regulation of neuron differentiation; positive regulation of phagocytosis; positive regulation of phagocytosis, engulfment; positive regulation of transcription from RNA polymerase II promoter; regulation of forebrain neuron differentiation; regulation of hematopoietic stem cell differentiation; regulation of histone acetylation; regulation of primitive erythrocyte differentiation; response to lipid; somatic stem cell maintenance; transcription from RNA polymerase II promoter; transcription, DNA-dependent; urogenital system development; ventral spinal cord interneuron differentiation

Disease: Immunodeficiency 21; Lymphedema, Primary, With Myelodysplasia; Myelodysplastic Syndrome

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