For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of GATA2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9375734 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Gata Binding Protein 2 (GATA2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing GATA2. The ELISA analytical biochemical technique of the MBS9375734 kit is based on GATA2 antibody-GATA2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect GATA2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, GATA2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

49,106 Da

GATA binding protein 2

endothelial transcription factor GATA-2

Endothelial transcription factor GATA-2

GATA2_HUMAN

This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

GATA2: Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. Endothelial cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: nucleoplasm; nucleus; transcription factor complex

Molecular Function: chromatin binding; protein binding; transcription factor activity; transcription factor binding

Biological Process: blood coagulation; gut development; heart development; negative regulation of fat cell differentiation; negative regulation of Notch signaling pathway; organ morphogenesis; positive regulation of angiogenesis; positive regulation of phagocytosis; positive regulation of transcription from RNA polymerase II promoter; tissue development; transcription, DNA-dependent

Disease: Immunodeficiency 21; Lymphedema, Primary, With Myelodysplasia; Myelodysplastic Syndrome

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