For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of SCNN1A elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9374291 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Amiloride Sensitive Sodium Channel Subunit Alpha (SCNN1A) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SCNN1A. The ELISA analytical biochemical technique of the MBS9374291 kit is based on SCNN1A antibody-SCNN1A antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SCNN1A antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SCNN1A. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

78,888 Da

sodium channel epithelial 1 alpha subunit

amiloride-sensitive sodium channel subunit alpha

Amiloride-sensitive sodium channel subunit alpha

Renac; Alpha-ENaC??[Similar Products]

SCNNA_RAT

acts as an epithelial sodium ion channel; regulates salt and fluid transport in the kidney [RGD, Feb 2006]

ENaC-alpha: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Probable heterotrimer containing one alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2. By aldosterone. Highly expressed in kidney and lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart. Activated by WNK1, WNK2, WNK3 and WNK4. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter, ion channel; Channel, sodium; Membrane protein, integral

Cellular Component: apical plasma membrane; cortical actin cytoskeleton; cytosol; external side of plasma membrane; integral to membrane; integral to plasma membrane; membrane

Molecular Function: actin binding; amiloride-sensitive sodium channel activity; sodium channel activity; WW domain binding

Biological Process: multicellular organismal water homeostasis; regulation of blood pressure; regulation of body fluid levels; sodium ion homeostasis; sodium ion transport

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