Product Name
COMMD1, Polyclonal Antibody
Full Product Name
COMMD1 Antibody
Product Synonym Names
C2orf5; MGC27155; MURR1
Product Gene Name
anti-COMMD1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of COMMD1
Calculated Molecular Weight: 190aa; 21kd
Observed Molecular Weight: 21kd
Buffer
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-107497 / sc-107500 / sc-107498 / sc-98286
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-COMMD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-COMMD1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-COMMD1 antibody
WB: 1:1000-1:10000
IHC: 1:20-1:200
Testing Data of anti-COMMD1 antibody
NCBI/Uniprot data below describe general gene information for COMMD1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_689729.1
[Other Products]
NCBI GenBank Nucleotide #
NM_152516.2
[Other Products]
UniProt Secondary Accession #
Q96GS0; B4DFQ4[Other Products]
UniProt Related Accession #
Q8N668[Other Products]
Molecular Weight
17,665 Da
NCBI Official Full Name
COMM domain-containing protein 1
NCBI Official Synonym Full Names
copper metabolism (Murr1) domain containing 1
NCBI Official Symbol
COMMD1??[Similar Products]
NCBI Official Synonym Symbols
MURR1; C2orf5
??[Similar Products]
NCBI Protein Information
COMM domain-containing protein 1; copper metabolism gene MURR1; protein Murr1
UniProt Protein Name
COMM domain-containing protein 1
UniProt Synonym Protein Names
Protein Murr1
Protein Family
COMM domain-containing protein
UniProt Gene Name
COMMD1??[Similar Products]
UniProt Synonym Gene Names
C2orf5; MURR1??[Similar Products]
UniProt Entry Name
COMD1_HUMAN
NCBI Summary for COMMD1
COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009]
UniProt Comments for COMMD1
COMMD1: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 2p15
Cellular Component: Cul2-RING ubiquitin ligase complex; nucleoplasm; recycling endosome; early endosome; cytoplasmic membrane-bound vesicle; cytoplasm; endosome membrane; nucleus
Molecular Function: identical protein binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein homodimerization activity; phosphatidylinositol-3,4,5-triphosphate binding; copper ion binding; phosphatidylinositol-3,4-bisphosphate binding
Biological Process: Golgi to plasma membrane transport; protein transport; transcription, DNA-dependent; inhibition of NF-kappaB transcription factor; positive regulation of protein ubiquitination; regulation of proteasomal ubiquitin-dependent protein catabolic process; plasma membrane to endosome transport; copper ion homeostasis
Research Articles on COMMD1
1. These data demonstrate the anti-inflammatory properties of COMMD1 in bronchial epithelial cells and open new therapeutic avenues in cystic fibrosis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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