Product Name
COMMD1, cDNA Clone
Full Product Name
COMMD1 cDNA Clone
Product Gene Name
COMMD1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggcggcgg gcgagcttga gggtggcaaa cccctgagcg ggctgctgaa tgcgctggcc caggacactt tccacgggta ccccggcatc acagaggagc tgctacggag ccagctatat ccagaggtgc cacccgagga gttccgcccc tttctggcaa agatgagggg gattcttaag tctattgcgt ctgcagacat ggatttcaac cagctggagg cattcttgac tgctcaaacc aaaaagcaag gtgggatcac atctgaccaa gctgctgtca tttccaaatt ctggaagagc cacaagacaa aaatccgtga gagcctcatg aaccagagcc gctggaatag cgggcttcgg ggcctgagct ggagagttga tggcaagtct cagtcaaggc actcagctca aatacacaca cctgttgcca ttatagagct ggaattaggc aaatatggac aggaatctga atttctgtgt ttggaatttg acgaggtcaa agtcaaccaa attctgaaga cgctgtcaga ggtagaagaa agtatcagca cactgatcag ccagcctaac tga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of COMMD1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for COMMD1. It may not necessarily be applicable to this product.
NCBI Accession #
BC022046
[Other Products]
UniProt Secondary Accession #
Q96GS0; B4DFQ4[Other Products]
UniProt Related Accession #
Q8N668[Other Products]
Molecular Weight
17,665 Da
NCBI Official Full Name
Homo sapiens copper metabolism (Murr1) domain containing 1, mRNA
NCBI Official Synonym Full Names
copper metabolism domain containing 1
NCBI Official Symbol
COMMD1??[Similar Products]
NCBI Official Synonym Symbols
MURR1; C2orf5
??[Similar Products]
NCBI Protein Information
COMM domain-containing protein 1
UniProt Protein Name
COMM domain-containing protein 1
UniProt Synonym Protein Names
Protein Murr1
Protein Family
COMM domain-containing protein
UniProt Gene Name
COMMD1??[Similar Products]
UniProt Synonym Gene Names
C2orf5; MURR1??[Similar Products]
UniProt Entry Name
COMD1_HUMAN
NCBI Summary for COMMD1
COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009]
UniProt Comments for COMMD1
COMMD1: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 2p15
Cellular Component: Cul2-RING ubiquitin ligase complex; cytoplasm; early endosome; nucleoplasm; nucleus; recycling endosome
Molecular Function: copper ion binding; identical protein binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; protein homodimerization activity
Biological Process: copper ion homeostasis; Golgi to plasma membrane transport; inhibition of NF-kappaB transcription factor; plasma membrane to endosome transport; positive regulation of protein ubiquitination; regulation of proteasomal ubiquitin-dependent protein catabolic process
Research Articles on COMMD1
1. COMMD1 expression is associated with poor prognosis in diffuse large B-cell lymphoma
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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