Product Name
Copper Metabolism Domain Containing 1 (COMMD1), Recombinant Protein
Full Product Name
Recombinant Human Copper Metabolism Domain Containing 1
Product Synonym Names
COMMD1 Human; Copper Metabolism Domain Containing 1 Human Recombinant; MURR1; C2orf5; COMMD1; Copper Metabolism Domain Containing 1; MGC27155
Product Gene Name
COMMD1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHH HHH SSGLVPRGSH MAAGELEGGK PLSGLLNALA QDTFHGYPGI TEELLRSQLY PEVPPEEFRP FLAKMRGILK SIASADMDFN QLEAFLTAQT KKQGGITSDQ AAVISKFWKS HKTKIRESLM NQSRWNSGLR GLSWRVDGKS QSRHSAQIHT PVAIIELELG KYGQESEFLC LEFDEVKVNQ ILKTLSEVEE SISTLISQPN
3D Structure
ModBase 3D Structure for Q8N668
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Form/Format
COMMD1 Human solution containing 20mM Trsi pH-8, 0.1M NaCl& 20% glycerol.
Sterile filtered colorless solution.
Preparation and Storage
COMMD1 Human although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.
Other Notes
Small volumes of COMMD1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
COMMD1 recombinant protein
Description: COMMD1 Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 210 amino acids (1-190 a.a.) and having a molecular mass of 23.3 kDa. The COMMD1 is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
Introduction: COMMD1 is accountable for inhibition of TNF-induced NFkappaB p50 and n facilitats of biliary copper excretion within hepatocytes. High expression of COMMD1 is localized in liver tissue, with lower expressions in lung, heart, kidney and brain tissue. COMMD1 interacts directly with COMMD6 and ATP7B, and indirectly with IkappaB-beta and COMMD7.
Product Categories/Family for COMMD1 recombinant protein
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for COMMD1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_689729.1
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NCBI GenBank Nucleotide #
NM_152516.2
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UniProt Primary Accession #
Q8N668
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UniProt Secondary Accession #
Q96GS0; B4DFQ4[Other Products]
UniProt Related Accession #
Q8N668[Other Products]
Molecular Weight
17,665 Da
NCBI Official Full Name
COMM domain-containing protein 1
NCBI Official Synonym Full Names
copper metabolism (Murr1) domain containing 1
NCBI Official Symbol
COMMD1??[Similar Products]
NCBI Official Synonym Symbols
MURR1; C2orf5
??[Similar Products]
NCBI Protein Information
COMM domain-containing protein 1; copper metabolism gene MURR1; protein Murr1
UniProt Protein Name
COMM domain-containing protein 1
UniProt Synonym Protein Names
Protein Murr1
Protein Family
COMM domain-containing protein
UniProt Gene Name
COMMD1??[Similar Products]
UniProt Synonym Gene Names
C2orf5; MURR1??[Similar Products]
UniProt Entry Name
COMD1_HUMAN
NCBI Summary for COMMD1
COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009]
UniProt Comments for COMMD1
COMMD1: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 2p15
Cellular Component: Cul2-RING ubiquitin ligase complex; nucleoplasm; recycling endosome; cytoplasm; early endosome; cytoplasmic membrane-bound vesicle; endosome membrane; nucleus
Molecular Function: identical protein binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; copper ion binding; protein homodimerization activity; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding
Biological Process: Golgi to plasma membrane transport; protein transport; transcription, DNA-dependent; positive regulation of protein ubiquitination; inhibition of NF-kappaB transcription factor; regulation of proteasomal ubiquitin-dependent protein catabolic process; plasma membrane to endosome transport; copper ion homeostasis
Research Articles on COMMD1
1. These data demonstrate the anti-inflammatory properties of COMMD1 in bronchial epithelial cells and open new therapeutic avenues in cystic fibrosis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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