For Research Use Only. Not for use in diagnostic procedures.

Rabbit

Lyophilized; PBS, pH 7.2

Small volumes of anti-SERPINI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ELISA (EIA), Western Blot (WB)

The Recombinant immunogen was migrated by 12% SDS-PAGE and transferred to a 0.2 um PVDF membrane. After blocking the membrane in blocking buffer (5% milk powder in 20 mM Tris-HCl pH 7.5, 500 mM NaCl, 0.1% (v/v) Tween 20 , the membrane was incubated with biotinylated primary antibody (0.1ug/ml) at 4 degree C overnight. Enhanced chemiluminescence (ECL) reagents were used to visualize

96-well maxisorp plates were coated with the capture antibody overnight, then blocked with 5% FCS in PBS for 1?hour, then washed. Then, the protein standard was added, and plates were incubated for 2?hrs at 37 degree C. Plates were washed and incubated with a biotinylated detection antibody for 1?hour at 37 degree C. After washing, plates were incubated with HRP-conjugated streptavidin for 30?min at room temperature and washed again. Plates were developed using the tetramethylbenzidine peroxidase substrate system and absorbance was measured at 450-615?nm using an automated plate reader.

46,427 Da[Similar Products]

serpin family I member 1

neuroserpin

Neuroserpin

PI12; PI-12??[Similar Products]

This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin (PubMed:9442076, PubMed:26329378, PubMed:19265707, PubMed:19285087, PubMed:11880376). May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the ***** nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable).

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