Serpin Family I Member; Serine (Or Cysteine) Proteinase Inhibitor; Clade I (Neuroserpin); Member 1; Serpin Peptidase Inhibitor; Clade I (Neuroserpin); Member 1; Peptidase Inhibitor 12; Serpin I1; PI-12; PI12; Serpin Peptidase Inhibitor Clade I Member 1; Neuroserpin

For Research Use Only. Not for use in diagnostic procedures.

The OmniKine Human Neuroserpin ELISA is capable of recognizing both recombinant and naturally produced Human Neuroserpin proteins. The antigens listed below were tested at 50ng/ml the following antigens did not exhibit significant cross reactivity
Human Maspin, PAI-1, PAI-2, PEDF, Vaspin

12 x 8-Well Microstrips

Store at 4 degree C for 6 months.

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of SERPINI1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9502108 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Neuroserpin (SERPINI1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SERPINI1. The ELISA analytical biochemical technique of the MBS9502108 kit is based on SERPINI1 antibody-SERPINI1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SERPINI1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SERPINI1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

46,427 Da

serpin family I member 1

neuroserpin

Neuroserpin

PI12; PI-12??[Similar Products]

This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

SERPINI1: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the ***** nervous system. May protect neurons from cell damage by tissue-type plasminogen activator. Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B). FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin. Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q26.1

Cellular Component: cell soma; extracellular space; perikaryon

Molecular Function: serine-type endopeptidase inhibitor activity

Biological Process: central nervous system development; peripheral nervous system development; regulation of cell adhesion

Disease: Encephalopathy, Familial, With Neuroserpin Inclusion Bodies

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