Product Name
Antizyme inhibitor 2 (Adc), Recombinant Protein
Full Product Name
Recombinant Mouse Antizyme inhibitor 2 (Adc)
Product Gene Name
Adc recombinant protein
[Similar Products]
Product Synonym Gene Name
Adc[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-459aa, full length protein
Sequence
MAGYLSESDF VMVEEGFSTR DLLEELTLGA SQATSGKVAA FFVADLGAVV RKHFCFLKHL PRVRPFYAVG CNSSLGVLKV LAELGLGFSC ANKAEMELVQ HIGVPASKII CANPCKQVAQ IKYAAKHGVR LLSFDNEVEL AKVVKSHPSA KMVLCIATQD SHSLNHLSLR FGASLKSCRH LLENAKKSHV EVVGVSFHIG SGCPDPQAYA QSIADARLVF QMGEELGHTM NILDLGGGFP GLEGAKVRFE EMASVINSAL DLYFPEGCGV DILAELGRYY VTSAFTVAVS IVAKREVLDQ ASREEQTGAA PKSIVYYLDE GVYGVFNSVL FDNTCPTPAL QKKPSADQPL YSSSLWGPAV EGCDCVAEGL WLPQLQVGDW LVFDNMGAYT VDTKSLLGGT QARRVTYAMS RLAWEALRGQ LLPAEEDQDA EGVCKPLSCG WEITDTLCVG PVFTPASIM
3D Structure
ModBase 3D Structure for Q8BVM4
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Adc recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Adc. It may not necessarily be applicable to this product.
NCBI Accession #
NP_766463.1
[Other Products]
NCBI GenBank Nucleotide #
NM_172875.4
[Other Products]
UniProt Primary Accession #
Q8BVM4
[Other Products]
UniProt Secondary Accession #
A2A823[Other Products]
UniProt Related Accession #
Q8BVM4[Other Products]
Molecular Weight
49,503 Da
NCBI Official Full Name
antizyme inhibitor 2 isoform 1
NCBI Official Synonym Full Names
antizyme inhibitor 2
NCBI Official Symbol
Azin2??[Similar Products]
NCBI Official Synonym Symbols
Adc; Azi2; Odcp; ODC-p; B930082O19; 4933429I20Rik
??[Similar Products]
NCBI Protein Information
antizyme inhibitor 2
UniProt Protein Name
Antizyme inhibitor 2
UniProt Synonym Protein Names
Arginine decarboxylase-like protein; ADC; ARGDC; Ornithine decarboxylase-like protein; ODC-like protein; ornithine decarboxylase paralog; ODC-p
Protein Family
Acetoacetate decarboxylase
UniProt Gene Name
Azin2??[Similar Products]
UniProt Synonym Gene Names
Adc; Odcp; AzI2; ADC; ARGDC; ODC-like protein; ODC-p??[Similar Products]
NCBI Summary for Adc
The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
UniProt Comments for Adc
Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:18062773, PubMed:18508777, PubMed:18973822). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:16916800, PubMed:24967154). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking ().
Research Articles on Adc
1. show, for the first time, an element of polyamine metabolism -AZIN2-, so far described as exclusively devoted to the control of polyamine concentrations, involved in regulating the biosynthesis and content of other amines like serotonin and histamine.
Precautions
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Disclaimer
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