Full Product Name
EVC Polyclonal Antibody
Product Synonym Names
DWF-1; EVC1; EVCL
Product Gene Name
anti-EVC antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P57679
Purity/Purification
Affinity Purification
Immunogen
Recombinant protein of human EVC
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-EVC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-EVC antibody
This gene encodes a protein containing a leucine zipper and a transmembrane domain. This gene has been implicated in both Ellis-van Creveld syndrome (EvC) and Weyers acrodental dysostosis.
Product Categories/Family for anti-EVC antibody
Primary antibody
Applications Tested/Suitable for anti-EVC antibody
Western Blot (WB)
Application Notes for anti-EVC antibody
WB: 1:1000 - 1:3000
Western Blot (WB) of anti-EVC antibody
Western blot analysis of extracts of mouse kidney, using EVC antibody at 1:3000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 10s.
NCBI/Uniprot data below describe general gene information for EVC. It may not necessarily be applicable to this product.
NCBI Accession #
P57679.1
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UniProt Primary Accession #
P57679
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UniProt Related Accession #
P57679[Other Products]
NCBI Official Full Name
Ellis-van Creveld syndrome protein
NCBI Official Synonym Full Names
EvC ciliary complex subunit 1
NCBI Official Symbol
EVC??[Similar Products]
NCBI Official Synonym Symbols
EVC1; EVCL; DWF-1
??[Similar Products]
NCBI Protein Information
ellis-van Creveld syndrome protein
UniProt Protein Name
Ellis-van Creveld syndrome protein
UniProt Synonym Protein Names
DWF-1
Protein Family
Ellis-van Creveld syndrome protein
UniProt Gene Name
EVC??[Similar Products]
NCBI Summary for EVC
This gene encodes a protein containing a leucine zipper and a transmembrane domain. This gene has been implicated in both Ellis-van Creveld syndrome (EvC) and Weyers acrodental dysostosis. [provided by RefSeq, Jul 2008]
UniProt Comments for EVC
EVC: Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development. Defects in EVC are a cause of Ellis-van Creveld syndrome (EVC); also known as chondroectodermal dysplasia. EVC is an autosomal recessive disorder characterized by the clinical tetrad of chondrodystrophy, polydactyly, ectodermal dysplasia and cardiac anomalies. Patients manifest short-limb dwarfism, short ribs, postaxial polydactyly and dysplastic nails and teeth. Congenital heart defects, most commonly an atrioventricular septal defect, are observed in 60% of affected individuals. Defects in EVC are a cause of acrofacial dysostosis Weyers type (WAD); also known as Curry-Hall syndrome. Acrofacial dysostoses are a heterogeneous group of disorders combining limb defects with facial abnormalities. WAD is an autosomal dominant disorder characterized by dysplastic nails, postaxial polydactyly, acrofacial dysostosis, short limbs and short stature. The phenotype is milder than Ellis-van Creveld syndrome.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 4p16.2
Cellular Component: cilium
Biological Process: muscle development; positive regulation of smoothened signaling pathway; skeletal development
Disease: Ellis-van Creveld Syndrome; Weyers Acrofacial Dysostosis
Research Articles on EVC
1. we detected two novel nonsense mutations and a partial deletion of EVC/EVC2 in two Vietnamese families with EvC. Moreover, we found in one family a missense mutation of EFCAB7, a possible modifier gene in EvC and its related disorders.
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