Product Name
Neuroserpin (SERPINI1), Polyclonal Antibody
Full Product Name
Neuroserpin antibody
Product Synonym Names
Polyclonal Neuroserpin; Anti-Neuroserpin; Serpin I1; Protease inhibitor 12
Product Gene Name
anti-SERPINI1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q99574
Species Reactivity
Human neuroserpin
Form/Format
Lyophilized from PBS, pH 7.2.
Biological Significance
Neuroserpin is an inhibitory serpin that is expressed predominantly in central nervous system. Although the physiological target of neuroserpin is still unclear, cumulative evidence suggest that it plays an important role in controlling proteolytic degradation of extracellular matrix (ECM) during synaptogenesis and the subsequent development of neuronal plasticity. In the ***** brain, neuroserpin is secreted from the growth cones of neurons in areas where synaptic changes are associated with learning and memory, i.e. cerebral cortex, hippocampus, and amygdala.
Immunogen
Neuroserpin antibody was raised in rabbit using highly pure recombinant human neuroserpin as the immunogen.
Preparation and Storage
Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-SERPINI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SERPINI1 antibody
Affinity purified Rabbit polyclonal Neuroserpin antibody
Product Categories/Family for anti-SERPINI1 antibody
Neuroscience; Purified Polyclonal Antibodies
Applications Tested/Suitable for anti-SERPINI1 antibody
ELISA (EIA), Inhibition, Western Blot (WB)
NCBI/Uniprot data below describe general gene information for SERPINI1. It may not necessarily be applicable to this product.
NCBI Accession #
CAB03626.1
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UniProt Primary Accession #
Q99574
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UniProt Secondary Accession #
Q6AHZ4; A8K217; D3DNP1[Other Products]
Molecular Weight
44.6 kDa (predicted detection band MW)[Similar Products]
NCBI Official Full Name
neuroserpin
UniProt Protein Name
Neuroserpin
UniProt Synonym Protein Names
Peptidase inhibitor 12; PI-12; Serpin I1
Protein Family
Neuroserpin
UniProt Gene Name
SERPINI1??[Similar Products]
UniProt Synonym Gene Names
PI12; PI-12??[Similar Products]
UniProt Entry Name
NEUS_HUMAN
UniProt Comments for SERPINI1
SERPINI1: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the ***** nervous system. May protect neurons from cell damage by tissue-type plasminogen activator. Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B). FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin. Belongs to the serpin family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 3q26.1
Cellular Component: extracellular space
Molecular Function: serine-type endopeptidase inhibitor activity
Biological Process: regulation of cell adhesion; central nervous system development; peripheral nervous system development
Disease: Encephalopathy, Familial, With Neuroserpin Inclusion Bodies
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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