Chloride channel protein 1; Chloride channel protein; Chloride channel protein skeletal muscle; CIC 1; CIC1; ClC-1; CLC1; Clcn1; CLCN1_HUMAN; MGC138361; MGC142055; skeletal muscle

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

CLCN1 antibody detects endogenous levels of total CLCN1

The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.

Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1mg/ml (lot specific)

Store at -20 degree C. Stable for 12 months from date of receipt.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.

Small volumes of anti-CLCN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Function: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
Subunit Structure: Homodimer.
Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily.

Western Blot (WB), ELISA (EIA)

WB: 1:1000-3000

Western blot analysis of CLCN1 using K562 whole cell lysates

Observed: 109 kDa
Predicted: 109 kDa

chloride voltage-gated channel 1

chloride channel protein 1

Chloride channel protein 1

CLC1; ClC-1??[Similar Products]

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

Voltage-gated chloride channel (PubMed:8112288, PubMed:9122265, PubMed:12456816). Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction.

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