Full Product Name
EVC2 Antibody, HRP conjugated
Product Synonym Names
Limbin; Ellis-van Creveld syndrome protein 2; EVC2; EVC2; LBN
Product Gene Name
anti-EVC2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q86UK5
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Limbin protein (30-199AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-EVC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-EVC2 antibody
Positive regulator of the hedgehog signaling pathway (By similarity). Plays a critical role in bone formation and skeletal development.
Product Categories/Family for anti-EVC2 antibody
Others
Applications Tested/Suitable for anti-EVC2 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for EVC2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001159608.1
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NCBI GenBank Nucleotide #
NM_001166136.1
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UniProt Primary Accession #
Q86UK5
[Other Products]
UniProt Secondary Accession #
Q86YT3; Q86YT4; Q8NG49[Other Products]
UniProt Related Accession #
Q86UK5[Other Products]
Molecular Weight
141,159 Da
NCBI Official Full Name
limbin isoform 2
NCBI Official Synonym Full Names
EvC ciliary complex subunit 2
NCBI Official Symbol
EVC2??[Similar Products]
NCBI Official Synonym Symbols
LBN; WAD
??[Similar Products]
NCBI Protein Information
limbin
UniProt Protein Name
Limbin
UniProt Synonym Protein Names
Ellis-van Creveld syndrome protein 2; EVC2
UniProt Gene Name
EVC2??[Similar Products]
UniProt Synonym Gene Names
LBN; EVC2??[Similar Products]
NCBI Summary for EVC2
This gene encodes a protein that functions in bone formation and skeletal development. Mutations in this gene, as well as in a neighboring gene that lies in a head-to-head configuration, cause Ellis-van Creveld syndrome, an autosomal recessive skeletal dysplasia that is also known as chondroectodermal dysplasia. Mutations in this gene also cause acrofacial dysostosis Weyers type, also referred to as Curry-Hall syndrome, a disease that combines limb and facial abnormalities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
UniProt Comments for EVC2
Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis.
Research Articles on EVC2
1. we detected two novel nonsense mutations and a partial deletion of EVC/EVC2 in two Vietnamese families with EvC. Moreover, we found in one family a missense mutation of EFCAB7, a possible modifier gene in EvC and its related disorders.
Precautions
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Disclaimer
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