Product Name
Limbin (EVC2), Recombinant Protein
Full Product Name
Recombinant Bovine Limbin (EVC2), partial
Product Gene Name
EVC2 recombinant protein
[Similar Products]
Product Synonym Gene Name
EVC2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MKFSKEIEVF NPPLASSASS GPWVHSVFAF THSWPRKTLF KRDSAVTHRL YGDISRDFQG TSENGVIFQK CAVVSVQSEW PSAHVRLFVN NTRTPTAANL SDLFLLDNIT GLTIRESAGN QTSRGFQAFR KKFLQVGDSF SVSYTASLEA RDVGSGDILL LPAQLSFQSS SPNRTQLKAP FTITAEEKIT VLPNHGLHAA
3D Structure
ModBase 3D Structure for Q8MI28
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of EVC2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
EVC2 recombinant protein
This gene encodes a protein that functions in bone formation and skeletal development. Mutations in this gene, as well as in a neighboring gene that lies in a head-to-head configuration, cause Ellis-van Creveld syndrome, an autosomal recessive skeletal dysplasia that is also known as chondroectodermal dysplasia. Mutations in this gene also cause acrofacial dysostosis Weyers type, also referred to as Curry-Hall syndrome, a disease that combines limb and facial abnormalities. Alternative splicing results in multiple transcript variants.
NCBI/Uniprot data below describe general gene information for EVC2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_776352.1
[Other Products]
NCBI GenBank Nucleotide #
NM_173927.1
[Other Products]
UniProt Primary Accession #
Q8MI28
[Other Products]
UniProt Related Accession #
Q8MI28[Other Products]
Molecular Weight
137,812 Da
NCBI Official Full Name
limbin
NCBI Official Synonym Full Names
EvC ciliary complex subunit 2
NCBI Official Symbol
EVC2??[Similar Products]
NCBI Official Synonym Symbols
LBN
??[Similar Products]
NCBI Protein Information
limbin
UniProt Protein Name
Limbin
UniProt Gene Name
EVC2??[Similar Products]
UniProt Synonym Gene Names
LBN??[Similar Products]
UniProt Comments for EVC2
Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis.
Research Articles on EVC2
1. The presence of a 2 bp deletion in exon 19 (c.2993_2994ACdel) led to a premature stop codon in the coding sequence of bovine EVC2, and was concordant with the recessive pattern of inheritance in affected and carrier animals.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
