Full Product Name
CLCN5 Polyclonal Antibody
Product Synonym Names
H(+)/Cl(-) exchange transporter 5; Chloride channel protein 5; ClC-5; Chloride transporter ClC-5; CLCN5; CLCK2
Product Gene Name
anti-CLCN5 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P51795
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-CLCN5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CLCN5 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CLCN5 antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for CLCN5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000075.1
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NCBI GenBank Nucleotide #
NM_000084.4
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UniProt Primary Accession #
P51795
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UniProt Secondary Accession #
Q5JQD5; Q7RTN8; A1L475; B3KPN6[Other Products]
UniProt Related Accession #
P51795[Other Products]
NCBI Official Full Name
H(+)/Cl(-) exchange transporter 5 isoform b
NCBI Official Synonym Full Names
chloride voltage-gated channel 5
NCBI Official Symbol
CLCN5??[Similar Products]
NCBI Official Synonym Symbols
XRN; CLC5; XLRH; CLCK2; ClC-5; DENTS; NPHL1; NPHL2; hCIC-K2
??[Similar Products]
NCBI Protein Information
H(+)/Cl(-) exchange transporter 5
UniProt Protein Name
H(+)/Cl(-) exchange transporter 5
UniProt Synonym Protein Names
Chloride channel protein 5; ClC-5; Chloride transporter ClC-5
Protein Family
H(+)/Cl(-) exchange transporter
UniProt Gene Name
CLCN5??[Similar Products]
UniProt Synonym Gene Names
CLCK2; ClC-5??[Similar Products]
NCBI Summary for CLCN5
This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]
UniProt Comments for CLCN5
Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.
Research Articles on CLCN5
1. A, p.W402*) and FGF23 (c.526C>G, p.R176G) mutations were found in two patients from the remaining two families">Novel CLCN5 (c.1205G>A, p.W402*) and FGF23 (c.526C>G, p.R176G) mutations were found in two patients from the remaining two families
Precautions
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Disclaimer
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