Full Product Name
Anti-CLCN5 Antibody
Product Synonym Names
CLCK2; H(+)/Cl(-) exchange transporter 5; Chloride channel protein 5; ClC-5; Chloride transporter ClC-5
Product Gene Name
anti-CLCN5 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P51795
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of CLCN5 protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
Recombinant full length protein of human CLCN5
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-CLCN5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CLCN5 antibody
Rabbit polyclonal antibody to CLCN5
Applications Tested/Suitable for anti-CLCN5 antibody
Western Blot (WB)
Application Notes for anti-CLCN5 antibody
WB: 1/500 - 1/2000
Western Blot (WB) of anti-CLCN5 antibody
Western blot analysis of CLCN5 expression in HepG2 (A), THP1 (B), mouse kidney (C), mouse brain (D) whole cell lysates.
NCBI/Uniprot data below describe general gene information for CLCN5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000075.1
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NCBI GenBank Nucleotide #
NM_000084.4
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UniProt Primary Accession #
P51795
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UniProt Secondary Accession #
Q5JQD5; Q7RTN8; A1L475; B3KPN6[Other Products]
UniProt Related Accession #
P51795[Other Products]
Molecular Weight
90,785 Da
NCBI Official Full Name
H(+)/Cl(-) exchange transporter 5 isoform b
NCBI Official Synonym Full Names
chloride voltage-gated channel 5
NCBI Official Symbol
CLCN5??[Similar Products]
NCBI Official Synonym Symbols
XRN; CLC5; XLRH; CLCK2; ClC-5; DENTS; NPHL1; NPHL2; hCIC-K2
??[Similar Products]
NCBI Protein Information
H(+)/Cl(-) exchange transporter 5
UniProt Protein Name
H(+)/Cl(-) exchange transporter 5
UniProt Synonym Protein Names
Chloride channel protein 5; ClC-5; Chloride transporter ClC-5
Protein Family
H(+)/Cl(-) exchange transporter
UniProt Gene Name
CLCN5??[Similar Products]
UniProt Synonym Gene Names
CLCK2; ClC-5??[Similar Products]
UniProt Entry Name
CLCN5_HUMAN
NCBI Summary for CLCN5
This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]
UniProt Comments for CLCN5
Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.
Research Articles on CLCN5
1. Previously reported mutations and their associated phenotype in 377 male patients with Dent disease are reviewed and described phenotype and novel and recurrent mutations in a large cohort of 117 Dent disease patients belonging to 90 families.
Precautions
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Disclaimer
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