Product Name
Retinoschisin (RS1), Polyclonal Antibody
Full Product Name
Rabbit anti-human Retinoschisin polyclonal Antibody(RS1), FITC
Product Synonym Names
X-linked juvenile retinoschisis protein; XLRS1; RS1
Product Gene Name
anti-RS1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O15537
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Immunogen
Recombinant human Retinoschisin protein(24-224AA)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-46480 / sc-46478 / sc-46477 / sc-48755
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-RS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-RS1 antibody
May be active in cell adhesion processes during retinal development.
Applications Tested/Suitable for anti-RS1 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for RS1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000321.1
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NCBI GenBank Nucleotide #
NM_000330.3
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UniProt Primary Accession #
O15537
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UniProt Secondary Accession #
Q0QD39[Other Products]
UniProt Related Accession #
O15537[Other Products]
Molecular Weight
25,592 Da
NCBI Official Full Name
retinoschisin
NCBI Official Synonym Full Names
retinoschisin 1
NCBI Official Symbol
RS1??[Similar Products]
NCBI Official Synonym Symbols
RS; XLRS1
??[Similar Products]
NCBI Protein Information
retinoschisin
UniProt Protein Name
Retinoschisin
UniProt Synonym Protein Names
X-linked juvenile retinoschisis protein
Protein Family
Retinoschisin
UniProt Gene Name
RS1??[Similar Products]
UniProt Synonym Gene Names
XLRS1??[Similar Products]
UniProt Entry Name
XLRS1_HUMAN
NCBI Summary for RS1
This gene encodes an extracellular protein that plays a crucial role in the cellular organization of the retina. The encoded protein is assembled and secreted from photoreceptors and bipolar cells as a homo-oligomeric protein complex. Mutations in this gene are responsible for X-linked retinoschisis, a common, early-onset macular degeneration in males that results in a splitting of the inner layers of the retina and severe loss in vision. [provided by RefSeq, Oct 2008]
UniProt Comments for RS1
RS1: a highly conserved extracellular protein essential for proper retinal structure. Must interact with L-type voltage-gated calcium channels (L-VGCCs) correctly so that the photoreceptor cells in the eye can function properly. Genetic mutations in RS1 cause X-linked retinoschisis (XLRS) and early onset of macular degeneration. Interacts with the L-VGCCa1D subunit, regulating its activity. The expression and secretion of retinoschisin are modulated by circadian rhythms, peaking at night and diminishing during the day.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: Xp22.13
Cellular Component: extracellular space; extrinsic to plasma membrane
Molecular Function: phosphatidylinositol 3-phosphate binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-5-phosphate binding; phosphatidylserine binding
Biological Process: adaptation of rhodopsin mediated signaling; cell adhesion; multicellular organismal development; visual perception
Disease: Retinoschisis 1, X-linked, Juvenile
Research Articles on RS1
1. We identified a novel causative mutation of RS1 in a Chinese family with X-linked juvenile retinoschisis.
Precautions
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Disclaimer
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