Full Product Name
KRT14, ID (Keratin, Type I Cytoskeletal 14, Cytokeratin-14, CK-14, Keratin-14, K14)
Product Synonym Names
Anti -KRT14, ID (Keratin, Type I Cytoskeletal 14, Cytokeratin-14, CK-14, Keratin-14, K14)
Product Gene Name
anti-KRT14 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000017.10 (39738531..39743147, complement). Location: 17q12-q21
3D Structure
ModBase 3D Structure for P02533
Specificity
Recognizes human KRT14.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Immunogen
Synthetic peptide selected from the Center region of human KRT14 (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-KRT14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KRT14 antibody
KRT14 is a member of the keratin family, the most diverse group of intermediate filaments. This protein, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells.
Product Categories/Family for anti-KRT14 antibody
Antibodies; Abs to Keratin, Cytokeratin
Applications Tested/Suitable for anti-KRT14 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-KRT14 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
NCBI/Uniprot data below describe general gene information for KRT14. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000517.2
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NCBI GenBank Nucleotide #
NM_000526.4
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UniProt Primary Accession #
P02533
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UniProt Secondary Accession #
Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4[Other Products]
UniProt Related Accession #
P02533; Q13092[Other Products]
Molecular Weight
51,561 Da[Similar Products]
NCBI Official Full Name
keratin, type I cytoskeletal 14
NCBI Official Synonym Full Names
keratin 14
NCBI Official Symbol
KRT14??[Similar Products]
NCBI Official Synonym Symbols
K14; NFJ; CK14; EBS3; EBS4
??[Similar Products]
NCBI Protein Information
keratin, type I cytoskeletal 14; CK-14; keratin-14; cytokeratin 14; cytokeratin-14; OTTHUMP00000164624; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)
UniProt Protein Name
Keratin, type I cytoskeletal 14
UniProt Synonym Protein Names
Cytokeratin-14; CK-14; Keratin-14
UniProt Gene Name
KRT14??[Similar Products]
UniProt Entry Name
K1C14_HUMAN
NCBI Summary for KRT14
This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq]
UniProt Comments for KRT14
K14: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K5.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q21.2
Cellular Component: cytoplasm; keratin filament; intermediate filament; cytosol; nucleus
Molecular Function: protein binding; structural constituent of cytoskeleton
Biological Process: hemidesmosome assembly; epidermis development; epithelial cell differentiation; response to zinc ion; response to ionizing radiation; intermediate filament bundle assembly; aging; hair cycle
Disease: Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa Simplex, Generalized; Dermatopathia Pigmentosa Reticularis; Epidermolysis Bullosa Simplex, Autosomal Recessive 1; Naegeli Syndrome; Epidermolysis Bullosa Simplex, Dowling-meara Type
Research Articles on KRT14
1. heterozygous G to A transition was found at nucleotide postion 1231 in exon 6 of KRT14 in family with epidermolysis bullosa simplex, generalized
Precautions
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Disclaimer
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