Product Name
MLKL, Blocking Peptide
Full Product Name
MLKL Peptide - N-terminal region
Product Gene Name
MLKL blocking peptide
[Similar Products]
Product Synonym Gene Name
FLJ34389[Similar Products]
MLKL peptide (MBS3236074) is used for blocking the activity of MLKL antibody (MBS3211122)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8NB16
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of MLKL blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
MLKL blocking peptide
This is a synthetic peptide designed for use in combination with anti-MLKL antibody made
Target Description: The specific function of this protein remains unknown.
Product Categories/Family for MLKL blocking peptide
Peptide
Applications Tested/Suitable for MLKL blocking peptide
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for MLKL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_689862
[Other Products]
NCBI GenBank Nucleotide #
NM_152649
[Other Products]
UniProt Primary Accession #
Q8NB16
[Other Products]
UniProt Related Accession #
Q8NB16[Other Products]
NCBI Official Full Name
mixed lineage kinase domain-like protein isoform 1
NCBI Official Synonym Full Names
mixed lineage kinase domain like pseudokinase
NCBI Official Symbol
MLKL??[Similar Products]
NCBI Official Synonym Symbols
hMLKL
??[Similar Products]
NCBI Protein Information
mixed lineage kinase domain-like protein
UniProt Protein Name
Mixed lineage kinase domain-like protein
Protein Family
Mixed lineage kinase domain-like protein
UniProt Gene Name
MLKL??[Similar Products]
UniProt Entry Name
MLKL_HUMAN
NCBI Summary for MLKL
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
UniProt Comments for MLKL
MLKL: Belongs to the protein kinase superfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); TKL group; TKL-Unique family
Chromosomal Location of Human Ortholog: 16q23.1
Cellular Component: cytoplasm; plasma membrane
Molecular Function: protein binding; protein complex binding; protein kinase binding; ATP binding; protein kinase activity
Biological Process: protein amino acid phosphorylation
Research Articles on MLKL
1. Following activation, toggling within the MLKL pseudokinase domain promotes 4HB domain disengagement from the pseudokinase domain alphaC helix and pseudocatalytic loop, to enable formation of a necroptosis-inducing tetramer.
Precautions
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Disclaimer
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