Full Product Name
DNM1 Polyclonal Antibody
Product Synonym Names
DNM
Product Gene Name
anti-DNM1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Concentration
2.7mg/mL (lot specific)
Immunogen
Synthetic peptide of human DNM1
Calculated Molecular Weight: 98kDa
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-DNM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DNM1 antibody
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.
Applications Tested/Suitable for anti-DNM1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-DNM1 antibody
WB: 1:200-1:1000
Western Blot (WB) of anti-DNM1 antibody
Western Blot analysis of Mouse brain tissue using DNM1 Polyclonal Antibody at dilution of 1:100
NCBI/Uniprot data below describe general gene information for DNM1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001275668.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001288739.1
[Other Products]
UniProt Secondary Accession #
Q5SYX0; Q5SYX2; Q6P3T6; Q86VD2; A6NLM6[Other Products]
UniProt Related Accession #
Q05193[Other Products]
Molecular Weight
95,895 Da
NCBI Official Full Name
dynamin-1 isoform 4
NCBI Official Synonym Full Names
dynamin 1
NCBI Official Symbol
DNM1??[Similar Products]
NCBI Official Synonym Symbols
DNM
??[Similar Products]
NCBI Protein Information
dynamin-1
UniProt Protein Name
Dynamin-1
UniProt Gene Name
DNM1??[Similar Products]
UniProt Synonym Gene Names
DNM??[Similar Products]
UniProt Entry Name
DYN1_HUMAN
NCBI Summary for DNM1
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
UniProt Comments for DNM1
DYN1: a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Concentrates within the presynaptic compartment and may participate in specialized neuronal functions such as rapid synaptic vesicle recycling. Part of a protein network that controls nucleation of actin from membranes. Contains one PH domain.
Protein type: Motor; EC 3.6.5.5; Vesicle; Motility/polarity/chemotaxis; Microtubule-binding; Hydrolase
Chromosomal Location of Human Ortholog: 9q34
Cellular Component: microtubule; membrane coat; plasma membrane
Molecular Function: GTPase activity; protein C-terminus binding; identical protein binding; protein binding; GTP binding; protein complex binding; nitric-oxide synthase binding; protein kinase binding
Biological Process: receptor-mediated endocytosis; axon guidance; endosome organization and biogenesis; receptor internalization; ephrin receptor signaling pathway; endocytosis
Disease: Epileptic Encephalopathy, Early Infantile, 31
Research Articles on DNM1
1. determined the alpha-synuclein-binding domain of beta-III tubulin and demonstrated that a short fragment containing this domain can suppress alpha-synuclein accumulation in the primary cultured cells
Precautions
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Disclaimer
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