Product Name
IFT122, Blocking Peptide
Full Product Name
IFT122 Peptide
Product Gene Name
IFT122 blocking peptide
[Similar Products]
Product Synonym Gene Name
SPG; WDR10; WDR10p; WDR140; CED[Similar Products]
IFT122 peptide (MBS3236482) is used for blocking the activity of IFT122 antibody (MBS3211533)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9HBG6
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of IFT122 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
IFT122 blocking peptide
This is a synthetic peptide designed for use in combination with anti-IFT122 antibody made
Target Description: IFT122 is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. IFT122 contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation.This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Product Categories/Family for IFT122 blocking peptide
Peptide
Applications Tested/Suitable for IFT122 blocking peptide
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for IFT122. It may not necessarily be applicable to this product.
NCBI Accession #
NP_443716
[Other Products]
NCBI GenBank Nucleotide #
NM_052990
[Other Products]
UniProt Primary Accession #
Q9HBG6
[Other Products]
UniProt Related Accession #
Q9HBG6[Other Products]
NCBI Official Full Name
intraflagellar transport protein 122 homolog isoform 4
NCBI Official Synonym Full Names
intraflagellar transport 122
NCBI Official Symbol
IFT122??[Similar Products]
NCBI Official Synonym Symbols
CED; SPG; CED1; WDR10; WDR10p; WDR140
??[Similar Products]
NCBI Protein Information
intraflagellar transport protein 122 homolog
UniProt Protein Name
Intraflagellar transport protein 122 homolog
UniProt Synonym Protein Names
WD repeat-containing protein 10; WD repeat-containing protein 140
Protein Family
Intraflagellar transport protein
UniProt Gene Name
IFT122??[Similar Products]
UniProt Synonym Gene Names
SPG; WDR10; WDR140??[Similar Products]
UniProt Entry Name
IF122_HUMAN
NCBI Summary for IFT122
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Mutations in this gene cause cranioectodermal dysplasia-1. A related pseudogene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Research Articles on IFT122
1. All the nine probands with syndromic craniosynostosis were found to carry the possibly causative variants, among which three variants including two missense mutations in IFT122 gene, in SMC1A gene and a frameshift mutation in TWIST1 gene have never been reported in patients before.
Precautions
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Disclaimer
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