Product Name
ARHGEF3, Polyclonal Antibody
Full Product Name
Anti-ARHGEF3 Antibody
Product Gene Name
anti-ARHGEF3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Immunogen
Recombinant protein of human ARHGEF3
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-ARHGEF3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ARHGEF3 antibody
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity.
Applications Tested/Suitable for anti-ARHGEF3 antibody
Western Blot (WB)
Application Notes for anti-ARHGEF3 antibody
WB: 1:500-1:2000
NCBI/Uniprot data below describe general gene information for ARHGEF3. It may not necessarily be applicable to this product.
NCBI Accession #
AAH99715.1
[Other Products]
UniProt Secondary Accession #
Q4FZB6; Q4QQI5; Q4QQQ0; Q59F00; Q6NUN3; Q7Z4U2; Q7Z5T2; Q9H7T4; A8K5U7[Other Products]
UniProt Related Accession #
Q9NR81[Other Products]
Molecular Weight
36,981 Da
NCBI Official Full Name
ARHGEF3 protein
NCBI Official Synonym Full Names
Rho guanine nucleotide exchange factor 3
NCBI Official Symbol
ARHGEF3??[Similar Products]
NCBI Official Synonym Symbols
GEF3; STA3; XPLN
??[Similar Products]
NCBI Protein Information
rho guanine nucleotide exchange factor 3
UniProt Protein Name
Rho guanine nucleotide exchange factor 3
UniProt Synonym Protein Names
Exchange factor found in platelets and leukemic and neuronal tissues; XPLN
Protein Family
Rho guanine nucleotide exchange factor
UniProt Gene Name
ARHGEF3??[Similar Products]
UniProt Synonym Gene Names
XPLN??[Similar Products]
NCBI Summary for ARHGEF3
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell
biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ARHGEF3
Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.
Research Articles on ARHGEF3
1. This is the first study describing the involvement of XPLN in the regulation of the mTORC2-SPARC axis, and these findings may help uncover regulatory mechanisms mediated by XPLN in idiopathic pulmonary fibrosis
Precautions
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Disclaimer
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