Full Product Name
GPR143 Antibody
Product Synonym Names
G-protein coupled receptor 143; Ocular albinism type 1 protein; GPR143; OA1
Product Gene Name
anti-GPR143 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P51810
Species Reactivity
Human, Mouse
Specificity
GPR143 antibody detects endogenous levels of total GPR143 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human GPR143.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-GPR143 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-GPR143 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-GPR143 antibody
Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-GPR143 antibody
IF: 1:100-1:500
ELISA: 1:10000
Immunofluorescence (IF) of anti-GPR143 antibody
Peptide-+ Immunofluorescence analysis of LOVO cells, using GPR143 antibody.
NCBI/Uniprot data below describe general gene information for GPR143. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000264.2
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NCBI GenBank Nucleotide #
NM_000273.2
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UniProt Primary Accession #
P51810
[Other Products]
UniProt Secondary Accession #
Q6NTI7[Other Products]
UniProt Related Accession #
P51810[Other Products]
Molecular Weight
43,878 Da
NCBI Official Full Name
G-protein coupled receptor 143
NCBI Official Synonym Full Names
G protein-coupled receptor 143
NCBI Official Symbol
GPR143??[Similar Products]
NCBI Official Synonym Symbols
OA1; NYS6
??[Similar Products]
NCBI Protein Information
G-protein coupled receptor 143
UniProt Protein Name
G-protein coupled receptor 143
UniProt Synonym Protein Names
Ocular albinism type 1 protein
Protein Family
G-protein coupled receptor
UniProt Gene Name
GPR143??[Similar Products]
UniProt Synonym Gene Names
OA1??[Similar Products]
NCBI Summary for GPR143
This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009]
UniProt Comments for GPR143
Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca2+ influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.
Product References and Citations for anti-GPR143 antibody
Bassi M.T., Nat. Genet. 10:13-19(1995). Ross M.T., Nature 434:325-337(2005). Mural R.J., Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Research Articles on GPR143
1. The findings of the present study expanded the gene mutation spectrum of GPR143 and investigated the clinical phenotype of patients with OA1 in the Chinese population.
Precautions
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Disclaimer
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