For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Purified by protein A column containing 0.02% NaN3

Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at-20 degree C.

Small volumes of anti-gpr143 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Rabbit polyclonal anti-gpr143(1) antibody was raised against a 15 amino acid peptide from near the C terminal residues of human anti-gpr143 protein.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

Peptide ELISA (EIA), Western Blot (WB)

Peptide ELISA: 1:1,000-1:5,000
WB: 1:200-500

43,878 Da

G protein-coupled receptor 143

G-protein coupled receptor 143

G-protein coupled receptor 143

OA1??[Similar Products]

This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009]

Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca2+ influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.

(1) Zhou, P., Wang, Z., Zhang, J., et al. Identification of a novel GPR143 deletion in a Chinese family with X-linked congenital nystagmus. (er) Mol. Vis. 14, 1015-1019 (2008).

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