Product Name
Surfactant Associated Protein G (SPG), Polyclonal Antibody
Full Product Name
Biotin-Linked Polyclonal Antibody to Surfactant Associated Protein G (SPG)
Product Synonym Names
SP-G; SFTPG; SFTA2; Surfactant Associated 2
Product Gene Name
anti-SPG antibody
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Matching Pairs
Unconjugated Antibody: Surfactant Associated Protein G (MBS2025968)
Biotin Conjugated Antibody: Surfactant Associated Protein G (SPG) (MBS2095480)
Matching Pairs
Biotin Conjugated Antibody: Surfactant Associated Protein G (SPG) (MBS2095480)
Immunogen: Surfactant Associated Protein G (MBS2031722)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Concentration
200ug/ml (lot specific)
Immunogen
SPG (Thr20~Thr78)
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.
Other Notes
Small volumes of anti-SPG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SPG antibody
Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for SPG. It may not necessarily be applicable to this product.
NCBI Accession #
AAG13415.1
[Other Products]
UniProt Secondary Accession #
Q53G36; Q8TC06; Q9BTB9; B3KW53; B4DEY9; B4DPW7; E7EQF4; E9PDG2; E9PDX2; G3XAB1; H7C3C0[Other Products]
UniProt Related Accession #
Q9HBG6[Other Products]
Molecular Weight
113,230 Da
NCBI Official Full Name
SPG protein
NCBI Official Synonym Full Names
intraflagellar transport 122
NCBI Official Symbol
IFT122??[Similar Products]
NCBI Official Synonym Symbols
CED; SPG; CED1; WDR10; WDR10p; WDR140
??[Similar Products]
NCBI Protein Information
intraflagellar transport protein 122 homolog
UniProt Protein Name
Intraflagellar transport protein 122 homolog
UniProt Synonym Protein Names
WD repeat-containing protein 10; WD repeat-containing protein 140
Protein Family
Immunoglobulin G-binding protein
UniProt Gene Name
IFT122??[Similar Products]
UniProt Synonym Gene Names
SPG; WDR10; WDR140??[Similar Products]
NCBI Summary for SPG
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Mutations in this gene cause cranioectodermal dysplasia-1. A related pseudogene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
UniProt Comments for SPG
Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia ().
Research Articles on SPG
1. All the nine probands with syndromic craniosynostosis were found to carry the possibly causative variants, among which three variants including two missense mutations in IFT122 gene, in SMC1A gene and a frameshift mutation in TWIST1 gene have never been reported in patients before.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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