Product Name
Aromatase, Positive Control
Full Product Name
Aromatase Positive Control
Product Synonym Names
Western Blot Positive Control Aromatase; ARO antibody; ARO1 antibody; Aromatase antibody; CP19A_HUMAN antibody; CPV1 antibody; CYAR antibody; Cyp19a1 antibody; CYPXIX antibody; Cytochrome P-450AROM antibody; Cytochrome P450, family 19, subfamily A, polypeptide 1 antibody; Cytochrome P450, subfamily XIX (aromatization of androgens) antibody; Estrogen synthase antibody; Flavoprotein linked monooxygenase antibody; Microsomal monooxygena; 450AROM antibody
Product Gene Name
ARO positive control
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P11511
Immunogen
Purified protein.
Molecular Function
aromatase activity; electron carrier activity; heme binding; iron ion binding
Subcellular Location
Membrane; Peripheral membrane protein
Preparation and Storage
Store at -20 degree C for long term storage.
Other Notes
Small volumes of ARO positive control vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ARO positive control
Overview: Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Structure: Belongs to the cytochrome P450 family.
Expression: Widely expressed, including in ***** and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads.
Applications Tested/Suitable for ARO positive control
Western Blot (WB)
Application Notes for ARO positive control
WB: 1:2,500-1:5,000
NCBI/Uniprot data below describe general gene information for ARO. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000094.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000103.3
[Other Products]
UniProt Primary Accession #
P11511
[Other Products]
UniProt Secondary Accession #
Q16731; Q3B764; Q58FA0; Q8IYJ7[Other Products]
UniProt Related Accession #
P11511[Other Products]
Molecular Weight
24,518 Da
NCBI Official Full Name
aromatase
NCBI Official Synonym Full Names
cytochrome P450 family 19 subfamily A member 1
NCBI Official Symbol
CYP19A1??[Similar Products]
NCBI Official Synonym Symbols
ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM
??[Similar Products]
NCBI Protein Information
aromatase
UniProt Protein Name
Aromatase
UniProt Synonym Protein Names
CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase
UniProt Gene Name
CYP19A1??[Similar Products]
UniProt Synonym Gene Names
ARO1; CYAR; CYP19??[Similar Products]
NCBI Summary for ARO
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
UniProt Comments for ARO
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Research Articles on ARO
1. Fungicide ziram may disrupt the placental steroid production. In the present study, we investigated the effects of ziram on steroid formation in human placental cell line JEG-3 cells and on HSD3B1 and aromatase in the human placenta. Ziram did not inhibit progesterone production in JEG-3 cells and HSD3B1 activity at 100muM... ziram is a potent inhibitor of human aromatase.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
