For Research Use Only. Not for use in diagnostic procedures.

50 ug (0.5 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA and 0.02% thimerosal.
Appearance: Colorless liquid

0.5 mg/ml (lot specific)

At -20 degree C
Shelf Life: 12 months

Small volumes of TLR5 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB)

The peptide is used for blocking antibody activity of TLR5. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30-60 minutes at 37 degree C.

97,627 Da

toll-like receptor 5

toll-like receptor 5

Toll-like receptor 5

TLR5_MOUSE

TLR5: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Genetic variation in TLR5 is associated with resistance to systemic lupus erythematosus type 1 (SLEB1). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Belongs to the Toll-like receptor family.

Protein type: Receptor, misc.; Membrane protein, integral

Cellular Component: membrane; integral to membrane

Molecular Function: protein binding; interleukin-1 receptor binding; transmembrane receptor activity

Biological Process: MyD88-dependent toll-like receptor signaling pathway; positive regulation of cytokine production; positive regulation of interleukin-8 production; toll-like receptor 5 signaling pathway; regulation of cytokine secretion; positive regulation of nitric oxide biosynthetic process; immune system process; defense response to bacterium; innate immune response; inflammatory response; signal transduction; positive regulation of toll-like receptor signaling pathway

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