Product Name
Integrin beta-3 (ITGB3), Recombinant Protein
Full Product Name
Integrin beta-3
Product Gene Name
ITGB3 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
27-788. Mature full length protein.
Sequence
GPNICTTRGV SSCQQCLAVS PMCAWCSDEA LPLGSPRCDL KENLLKDNCA PESIEFPVSE ARVLEDRPLS DKGSGDSSQV TQVSPQRIAL RLRPDDSKNF SIQVRQVEDY PVDIYYLMDL SYSMKDDLWS IQNLGTKLAT QMRKLTSNLR IGFGAFVDKP VSPYMYISPP EALENPCYDM KTTCLPMFGY KHVLTLTDQV TRFNEEVKKQ SVSRNRDAPE GGFDAIMQAT VCDEKIGWRN DASHLLVFTT DAKTHIALDG RLAGIVQPND GQCHVGSDNH YSASTTMDYP SLGLMTEKLS QKNINLIFAV TENVVNLYQN YSELIPGTTV GVLSMDSSNV LQLIVDAYGK IRSKVELEVR DLPEELSLSF NATCLNNEVI PGLKSCMGLK IGDTVSFSIE AKVRGCPQEK EKSFTIKPVG FKDSLIVQVT FDCDCACQAQ AEPNSHRCNN GNGTFECGVC RCGPGWLGSQ CECSEEDYRP SQQDECSPRE GQPVCSQRGE CLCGQCVCHS SDFGKITGKY CECDDFSCVR YKGEMCSGHG QCSCGDCLCD SDWTGYYCNC TTRTDTCMSS NGLLCSGRGK CECGSCVCIQ PGSYGDTCEK CPTCPDACTF KKECVECKKF DRGALHDENT CNRYCRDEIE SVKELKDTGK DAVNCTYKNE DDCVVRFQYY EDSSGKSILY VVEEPECPKG PDILVVLLSV MGAILLIGLA ALLIWKLLIT IHDRKEFAKF EEERARAKWD TANNPLYKEA TSTFTNITYR GT
3D Structure
ModBase 3D Structure for P05106
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Species
Homo sapiens (Human)
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ITGB3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ITGB3 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
Product Categories/Family for ITGB3 recombinant protein
Transmembrane Protein
NCBI/Uniprot data below describe general gene information for ITGB3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000203.2
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NCBI GenBank Nucleotide #
NM_000212.2
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UniProt Primary Accession #
P05106
[Other Products]
UniProt Secondary Accession #
O15495; Q12806; Q13413; Q14648; Q16499; A0PJW2; D3DXJ8[Other Products]
UniProt Related Accession #
P05106[Other Products]
Molecular Weight
86,694 Da
NCBI Official Full Name
integrin beta-3
NCBI Official Synonym Full Names
integrin subunit beta 3
NCBI Official Symbol
ITGB3??[Similar Products]
NCBI Official Synonym Symbols
GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16
??[Similar Products]
NCBI Protein Information
integrin beta-3
UniProt Protein Name
Integrin beta-3
UniProt Synonym Protein Names
Platelet membrane glycoprotein IIIa; GPIIIa; CD_antigen: CD61
UniProt Gene Name
ITGB3??[Similar Products]
UniProt Synonym Gene Names
GP3A; GPIIIa??[Similar Products]
UniProt Entry Name
ITB3_HUMAN
NCBI Summary for ITGB3
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]
UniProt Comments for ITGB3
ITGB3: integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIB/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: cell surface; filopodium membrane; focal adhesion; integral to plasma membrane; integrin complex; melanosome; microvillus membrane; nucleus; plasma membrane; platelet alpha granule membrane; receptor complex
Molecular Function: C-X3-C chemokine binding; cell adhesion molecule binding; coreceptor activity; enzyme binding; extracellular matrix binding; fibroblast growth factor binding; fibronectin binding; identical protein binding; insulin-like growth factor I binding; platelet-derived growth factor receptor binding; protease binding; protein binding; protein disulfide isomerase activity; vascular endothelial growth factor receptor 2 binding
Biological Process: activation of protein kinase activity; angiogenesis involved in wound healing; blood coagulation; cell adhesion; cell growth; cell migration; cell-matrix adhesion; cell-substrate adhesion; entry of virus into host cell; extracellular matrix organization and biogenesis; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; leukocyte migration; mesodermal cell differentiation; negative chemotaxis; negative regulation of lipid transport; negative regulation of lipoprotein metabolic process; negative regulation of low-density lipoprotein receptor biosynthetic process; platelet activation; platelet degranulation; positive regulation of endothelial cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of vascular endothelial growth factor receptor signaling pathway; regulation of bone resorption; smooth muscle cell migration; tube development; vascular endothelial growth factor receptor signaling pathway; wound healing
Disease: Bleeding Disorder, Platelet-type, 16; Glanzmann Thrombasthenia; Myocardial Infarction, Susceptibility To
Research Articles on ITGB3
1. The frequencies of the rare alleles of CCR2, ITGB3, and 3'UTR of c-fms in the Old Believers are lower than in the sample of Novosibirsk Russians, and the rare allele of DBH is more frequent
Precautions
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Disclaimer
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