Product Name
ADAMTS6, Polyclonal Antibody
Full Product Name
ADAMTS6 Antibody (N-Term)
Product Synonym Names
A disintegrin and metalloproteinase with thrombospondin motifs 6; ADAM-TS 6; ADAM-TS6; ADAMTS-6; 3424-; ADAMTS6
Product Gene Name
anti-ADAMTS6 antibody
[Similar Products]
Antibody/Peptide Pairs
ADAMTS6 peptide (MBS9229966) is used for blocking the activity of ADAMTS6 antibody (MBS9210131)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UKP5
Specificity
This ADAMTS6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 118-151 amino acids from the region of human ADAMTS6.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ADAMTS6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ADAMTS6 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ADAMTS6 antibody
WB~~1:2000
Western Blot (WB) of anti-ADAMTS6 antibody
All lanes : Anti-ADAMTS6 Antibody (N-Term) at 1:2000 dilution
Lane 1: Hela whole cell lysates
Lane 2: HT-1080 whole cell lysates
Lysates/proteins at 20 ug per lane.
Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution
Predicted band size : 125 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.
NCBI/Uniprot data below describe general gene information for ADAMTS6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_922932.2
[Other Products]
NCBI GenBank Nucleotide #
NM_197941.2
[Other Products]
UniProt Primary Accession #
Q9UKP5
[Other Products]
UniProt Secondary Accession #
Q59EX6; Q5IR87; Q5IR88; Q5IR89; Q68DL1[Other Products]
UniProt Related Accession #
Q9UKP5[Other Products]
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 6 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif, 6
NCBI Official Symbol
ADAMTS6??[Similar Products]
NCBI Official Synonym Symbols
ADAM-TS6; ADAMTS-6; ADAM-TS 6
??[Similar Products]
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 6
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 6
Protein Family
A disintegrin and metalloproteinase with thrombospondin motifs
UniProt Gene Name
ADAMTS6??[Similar Products]
UniProt Synonym Gene Names
ADAM-TS 6; ADAM-TS6; ADAMTS-6??[Similar Products]
UniProt Entry Name
ATS6_HUMAN
NCBI Summary for ADAMTS6
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. [provided by RefSeq, Jul 2008]
UniProt Comments for ADAMTS6
ADAMTS6: a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. [provided by RefSeq, Jul 2008]
Protein type: Secreted, signal peptide; Protease; Secreted; Motility/polarity/chemotaxis; EC 3.4.24.-
Chromosomal Location of Human Ortholog: 5q12
Cellular Component: proteinaceous extracellular matrix
Molecular Function: zinc ion binding; metallopeptidase activity; metalloendopeptidase activity
Biological Process: proteolysis
Product References and Citations for anti-ADAMTS6 antibody
Hurskainen T.L.,et al.J. Biol. Chem. 274:25555-25563(1999).
Bevitt D.J.,et al.Gene 359:99-110(2005).
Schmutz J.,et al.Nature 431:268-274(2004).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Research Articles on ADAMTS6
1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Precautions
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Disclaimer
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