Product Name
ataxia, cerebellar (ATCAY), Polyclonal Antibody
Full Product Name
Rabbit anti-human ataxia, cerebellar, Cayman type polyclonal Antibody
Product Synonym Names
ataxia; cerebellar; Cayman type; ATCAY; BNIP-H; CLAC; KIAA1872
Product Gene Name
anti-ATCAY antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-ATCAY antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ATCAY antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for ATCAY. It may not necessarily be applicable to this product.
NCBI Accession #
AAH26217.1
[Other Products]
UniProt Secondary Accession #
Q8NAQ2; Q8TAQ3; Q96HC6; Q96JF5[Other Products]
UniProt Related Accession #
Q86WG3[Other Products]
Molecular Weight
42,821 Da[Similar Products]
NCBI Official Full Name
Ataxia, cerebellar, Cayman type
NCBI Official Synonym Full Names
ataxia, cerebellar, Cayman type
NCBI Official Symbol
ATCAY??[Similar Products]
NCBI Official Synonym Symbols
CLAC; BNIP-H
??[Similar Products]
NCBI Protein Information
caytaxin; Cayman ataxia; BNIP-2-homolgy; BNIP-2-homology; ataxia cayman type protein
UniProt Protein Name
Caytaxin
UniProt Synonym Protein Names
Ataxia cayman type protein; BNIP-2-homology; BNIP-H
UniProt Gene Name
ATCAY??[Similar Products]
UniProt Synonym Gene Names
KIAA1872; BNIP-H??[Similar Products]
UniProt Entry Name
ATCAY_HUMAN
NCBI Summary for ATCAY
This gene encodes a neuron-restricted protein that contains a CRAL-TRIO motif common to proteins that bind small lipophilic molecules. Mutations in this gene are associated with cerebellar ataxia, Cayman type. [provided by RefSeq, Jul 2008]
UniProt Comments for ATCAY
ATCAY: Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites. Defects in ATCAY are the cause of cerebellar ataxia, cayman type (ATCAY). ATCAY is found in a population isolate on Grand Cayman Island and causes a marked psychomotor retardation and prominent nonprogressive cerebellar dysfunction including nystagmus, intention tremor, dysarthria, and wide-based ataxic gait. Hypotonia is present from early childhood. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: neuron projection; mitochondrion; axon; dendrite; cytoplasm; mitochondrial membrane; synapse; cell junction
Molecular Function: protein binding; kinesin binding
Biological Process: regulation of protein localization; apoptosis; transport; neurite development; mitochondrion distribution
Disease: Cerebellar Ataxia, Cayman Type
Research Articles on ATCAY
1. Caytaxin's role in maintaining normal neuronal function
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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