Anti -Activation-induced Cytidine Deaminase (AICDA, AID, ARP2, CDA2, HIGM2)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 12; NC_000012.11 (8754762..8765442, complement). Location: 12p13

Polyclonal

IgG

Rabbit

Recognizes human Activation-induced Cytidine Deaminase (AICDA, AID, ARP2, CDA2, HIGM2). Species Crossreactivity: mouse.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-AICDA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNAediting cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines (1). It is necessary for somatic hypermutation and class switch recombination in B cells (2), but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms (2,3). Although it is structurally and functionally similar to the APOBEC proteins (reviewed in 4), it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G (5).

Antibodies; Abs to Enzymes

ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC)

Suitable for use in ELISA, Western Blot, Immunocytochemistry.
Dilution: Western Blot: 1-2ug/ml. See Control Peptide, A0855-75J1.
Immunocytochemistry: 5-10ug/ml

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activation-induced cytidine deaminase

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Q546Y9_HUMAN

This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq]

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