Product Name
A disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAMTS13), Recombinant Protein
Full Product Name
A disintegrin and metalloproteinase with thrombospondin motifs 13
Product Synonym Names
Gm710; von Willebrand factor-cleaving protease; vWF-CP
Product Gene Name
ADAMTS13 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q769J6
Purity/Purification
>95% by SDS-PAGE
Endotoxin Level
<0.10 EU per 1 mug of the protein by the LAL method
Storage Buffer
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Preparation and Storage
Store at -20 degree C.
Avoid repeated freezing and thawing.
Other Notes
Small volumes of ADAMTS13 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for ADAMTS13 recombinant protein
ELISA (EIA), Western Blot (WB), Affinity Purification (AP), Protein Array
NCBI/Uniprot data below describe general gene information for ADAMTS13. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001001322.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001001322.2
[Other Products]
UniProt Primary Accession #
Q769J6
[Other Products]
UniProt Secondary Accession #
Q76LW1; A2ALB4[Other Products]
UniProt Related Accession #
Q769J6[Other Products]
Molecular Weight
155,357 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 13 isoform 1 preproprotein
NCBI Official Synonym Full Names
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13
NCBI Official Symbol
Adamts13??[Similar Products]
NCBI Official Synonym Symbols
Gm710; vWF-CP; ADAM-TS13; ADAMTS-13
??[Similar Products]
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 13
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 13
UniProt Synonym Protein Names
von Willebrand factor-cleaving protease; vWF-CP; vWF-cleaving protease
Protein Family
A disintegrin and metalloproteinase with thrombospondin motifs
UniProt Gene Name
Adamts13??[Similar Products]
UniProt Synonym Gene Names
Gm710; ADAM-TS 13; ADAM-TS13; ADAMTS-13; vWF-CP; vWF-cleaving protease??[Similar Products]
NCBI Summary for ADAMTS13
This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular
biology. In certain mouse strains (C57BL/6, for example) an intracisternal A-type particle (IAP) retrotransposon sequence is located in the intron 23 that causes an alternate splicing event resulting in a shorter transcript variants encoding shorter isoforms. The encoded preproprotein undergoes proteolytic processing to generate an active enzyme that cleaves von Willebrand factor (VWF) in circulating blood. [provided by RefSeq, Jul 2016]
UniProt Comments for ADAMTS13
Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation.
Research Articles on ADAMTS13
1. Adamts13 deficiency in obese mice promotes hepatic microthrombosis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
