Full Product Name
AADAC Polyclonal Antibody
Product Synonym Names
CES5A1; DAC
Product Gene Name
anti-AADAC antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P22760
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Immunogen
Recombinant protein of human AADAC
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-AADAC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AADAC antibody
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens
Product Categories/Family for anti-AADAC antibody
Primary antibody
Applications Tested/Suitable for anti-AADAC antibody
Western Blot (WB)
Application Notes for anti-AADAC antibody
WB: 1:500 - 1:2000
Western Blot (WB) of anti-AADAC antibody
Western blot analysis of extracts of various cell lines, using AADAC antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 30s.
NCBI/Uniprot data below describe general gene information for AADAC. It may not necessarily be applicable to this product.
NCBI Accession #
P22760.5
[Other Products]
UniProt Primary Accession #
P22760
[Other Products]
UniProt Secondary Accession #
Q8N1A9; A8K3L3; D3DNJ6[Other Products]
UniProt Related Accession #
P22760[Other Products]
NCBI Official Full Name
Arylacetamide deacetylase
NCBI Official Synonym Full Names
arylacetamide deacetylase
NCBI Official Symbol
AADAC??[Similar Products]
NCBI Official Synonym Symbols
DAC; CES5A1
??[Similar Products]
NCBI Protein Information
arylacetamide deacetylase
UniProt Protein Name
Arylacetamide deacetylase
Protein Family
Arylacetamide deacetylase
UniProt Gene Name
AADAC??[Similar Products]
UniProt Synonym Gene Names
DAC??[Similar Products]
NCBI Summary for AADAC
Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]
UniProt Comments for AADAC
AADAC: Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionaly causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores. Belongs to the 'GDXG' lipolytic enzyme family.
Protein type: Deacetylase; EC 3.1.1.3; Endoplasmic reticulum; Lipase; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3q25.1
Cellular Component: endoplasmic reticulum membrane
Molecular Function: catalytic activity; deacetylase activity; lipase activity; serine hydrolase activity; triacylglycerol lipase activity
Biological Process: catabolic process; xenobiotic metabolic process
Research Articles on AADAC
1. Data suggest that AADAC in hepatocyte microsomes hydrolyzes ketoconazole, a synthetic imidazole antifungal agent, to N-deacetyl ketoconazole and thus triggers hepatocellular toxicity.
Precautions
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Disclaimer
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