Human Protein FAM123B (FAM123B) ELISA kit; RP11-403E24.2; AMER1; FLJ39827; OSCS; WTX; Wilms tumor on the X; family with sequence similarity 123B

For Research Use Only. Not for use in diagnostic procedures.

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of FAM123B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9327537 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the family with sequence similarity 123B (FAM123B) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FAM123B. The ELISA analytical biochemical technique of the MBS9327537 kit is based on FAM123B antibody-FAM123B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FAM123B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FAM123B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of FAM123B (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

124,029 Da

APC membrane recruitment protein 1

APC membrane recruitment protein 1; RP11-403E24.2; protein FAM123B; Wilms tumor on the X; family with sequence similarity 123B; Wilms tumor gene on the X chromosome protein; adenomatous polyposis coli membrane recruitment 1

APC membrane recruitment protein 1

FAM123B; WTX; Amer1??[Similar Products]

AMER1_HUMAN

The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefSeq, May 2010]

WTX: a peripheral membrane protein on the cytoplasmic side that shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Enhances trancription activation by WT1. Promotes CTNNB1 ubiquitination and degradation. Antagonizes Wnt and CTNNB1 signaling. Inactivated in approximately one-third of Wilms tumors. Detected in fetal and ***** kidney, brain and spleen. Involved in kidney development. Interacts with CTNNB1, AXIN1, KEAP1, APC and BTRC. Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes containing BTRC and/or FBXW11. Identified in a complex containing CTNNB1, APC, AXIN1 and AXIN2. Two alternatively spliced human isoforms have been reported.

Chromosomal Location of Human Ortholog: Xq11.2

Cellular Component: plasma membrane; nucleus; cytosol

Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding; beta-catenin binding

Biological Process: Wnt receptor signaling pathway

Disease: Osteopathia Striata With Cranial Sclerosis

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