Product Name
N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein (Piga), Recombinant Protein
Full Product Name
Recombinant Mouse N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein (Piga), partial
Product Gene Name
Piga recombinant protein
[Similar Products]
Product Synonym Gene Name
Piga[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MANRRGGGQG QPPSVSPSPG SSGNLSDDRT CTHNICMVSD FFYPNMGGVE SHIYQLSQCL IERGHKVITV THAYGNRKGV RYLTNGLKVY YLPLRVMYNQ STATTLFHSL PLLRYIFVRE RITIIHSHSS FSAMAHDALF HAKTMGLQTV FTDHSLFGFA DVSSVLTNKL LTVSLCDTNH IICVSYTSKE NTVLRAALNP EIVSVIPNAV DPTDFTPDPF RRHDSVITVV VVSRLVYRKG TDLLSGIIPE LCQKYQELHF LIGGEGPKRI ILEEVRERYQ LHDRVQLLGA LEHKDVRNVL VQGHIFLNTS LTEAFCMAIV EAASCGLQVV STKVGGIPEV LPESLIILCE PSVKSLCDGL EKAIFQVKSG TLPAPENIHN VVKTFYTWRN VAERTEKVYE RVSKETVLPM HKRLDRLISH CG
3D Structure
ModBase 3D Structure for Q64323
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Piga recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Piga recombinant protein
This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized.
NCBI/Uniprot data below describe general gene information for Piga. It may not necessarily be applicable to this product.
NCBI Accession #
NP_035211.2
[Other Products]
NCBI GenBank Nucleotide #
NM_011081.3
[Other Products]
UniProt Primary Accession #
Q64323
[Other Products]
UniProt Secondary Accession #
Q6LD71; Q8CCQ6[Other Products]
UniProt Related Accession #
Q64323[Other Products]
Molecular Weight
54,469 Da
NCBI Official Full Name
N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein
NCBI Official Synonym Full Names
phosphatidylinositol glycan anchor biosynthesis, class A
NCBI Official Symbol
Piga??[Similar Products]
NCBI Official Synonym Symbols
Pig-a; AI194334
??[Similar Products]
NCBI Protein Information
N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein
UniProt Protein Name
N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein
UniProt Synonym Protein Names
GlcNAc-PI synthesis protein; Phosphatidylinositol-glycan biosynthesis class A protein; PIG-A
Protein Family
N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein
UniProt Gene Name
Piga??[Similar Products]
UniProt Synonym Gene Names
PIG-A??[Similar Products]
UniProt Comments for Piga
Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.
Research Articles on Piga
1. Pig-a mutations were identified in all clones developed from CD90-deficient cells; no Pig-a mutations were found in clones of CD90-proficient cells. The spectrum of B[a]P-induced Pig-a mutations was dominated by basepair substitutions, small insertions and deletions at G:C, or at sequences rich in G:C content.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
