Full Product Name
FATP4 antibody
Product Synonym Names
Polyclonal FATP4; anti-FATP4; Solute carrier family 27; FATP-4; FATP 4; FATP4; Fatty acid transporter member 4
Product Gene Name
anti-FATP4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q91VE0
Species Reactivity
Human, Mouse, Rat
Purity/Purification
FATP4 antibody was purified by affinity chromatography
Form/Format
Supplied in PBS buffer, pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.01% thimerosal
Concentration
500 ug/ml (lot specific)
Biological Significance
FATP4 is a transmembrane protein that is involved in the uptake and metabolism of long chain fatty acids. FATP4 has acyl-CoA synthase activity and contains an AMP-binding motif. FATP4 is linked to insulin resistance and metabolic disorders.
Immunogen
FATP4 antibody was raised in Rabbit using synthetic peptide surrounding amino acid 598 of rat FATP4 as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-FATP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FATP4 antibody
Rabbit polyclonal FATP4 antibody
Product Categories/Family for anti-FATP4 antibody
Proteases, Inhibitors, & Enzymes; Purified Polyclonal Antibodies
Applications Tested/Suitable for anti-FATP4 antibody
Western Blot (WB)
Application Notes for anti-FATP4 antibody
WB: 1-4 ug/ml
Western Blot (WB) of anti-FATP4 antibody
Western blot analysis of FATP4 using Jurkat cell lysate (Lane 1 & 2).
NCBI/Uniprot data below describe general gene information for FATP4. It may not necessarily be applicable to this product.
NCBI Accession #
AAC40188.1
[Other Products]
UniProt Primary Accession #
Q91VE0
[Other Products]
UniProt Secondary Accession #
O88562; Q3TD48[Other Products]
UniProt Related Accession #
Q91VE0[Other Products]
Molecular Weight
72,319 Da
NCBI Official Full Name
fatty acid transport protein 4, partial
NCBI Official Synonym Full Names
solute carrier family 27 (fatty acid transporter), member 4
NCBI Official Symbol
Slc27a4??[Similar Products]
NCBI Official Synonym Symbols
FATP4; BB144259
??[Similar Products]
NCBI Protein Information
long-chain fatty acid transport protein 4
UniProt Protein Name
Long-chain fatty acid transport protein 4
UniProt Synonym Protein Names
Solute carrier family 27 member 4
UniProt Gene Name
Slc27a4??[Similar Products]
UniProt Synonym Gene Names
Acsvl4; Fatp4; FATP-4; Fatty acid transport protein 4??[Similar Products]
UniProt Entry Name
S27A4_MOUSE
UniProt Comments for FATP4
SLC27A4: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Defects in SLC27A4 are the cause of ichthyosis prematurity syndrome (IPS). A keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations. Belongs to the ATP-dependent AMP-binding enzyme family.
Protein type: Transporter; Membrane protein, integral; EC 6.2.1.-; Ligase; Transporter, SLC family; Membrane protein, multi-pass
Cellular Component: endoplasmic reticulum membrane; microvillus; membrane; endoplasmic reticulum; brush border membrane; integral to membrane; plasma membrane
Molecular Function: branched-chain acyl-CoA synthetase (ADP-forming) activity; acyl-CoA ligase activity; succinate-CoA ligase activity; nucleotide binding; very-long-chain-fatty-acid-CoA ligase activity; 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity; 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity; 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0) CoA ligase activity; fatty-acid ligase activity; benzoyl acetate-CoA ligase activity; 2,4-dichlorobenzoate-CoA ligase activity; aryl-CoA synthetase (ADP-forming) activity; catalytic activity; ligase activity; long-chain-fatty-acid-CoA ligase activity
Biological Process: skin development; long-chain fatty acid transport; transport; very-long-chain fatty acid catabolic process; metabolic process; very-long-chain fatty acid metabolic process; lipid metabolic process; long-chain fatty acid metabolic process; lipid transport; medium-chain fatty acid transport; fatty acid metabolic process; fatty acid transport
Research Articles on FATP4
1. Transgenic expression of FATP1 in suprabasal keratinocytes rescued the phenotype of Fatp4 mutants, and FATP1 sorted to the same intracellular organelles as endogenous FATP4
Precautions
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Disclaimer
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