Full Product Name
Goat Polyclonal to Human AS3MT
Product Synonym Names
Anti-AS3MT Antibody (N-Terminus) IHC-plus; AS3MT; Arsenite methyltransferase; CYT19; Methyltransferase cyt19; RP11-753C18.6; Human AS3MT
Product Gene Name
anti-AS3MT antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9HBK9
Species Reactivity
Human
Predicted Reactivity: Gorilla, Orangutan, Gibbon, Rabbit (at least 90% immunogen sequence identity)
Purity/Purification
Immunoaffinity Purified
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Concentration
0.5 mg/ml (lot specific)
Usage Not Recommended
Western Blot (WB)
Immunogen Description
Synthetic peptide AALRDAEIQKDVQ-C from the N-terminus of human AS3MT (NP_065733.2). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (92%), Orangutan (92%), Gibbon (92%), Rabbit (92%), Rat (85%), Elephant (85%), Horse (85%).
Immunogen Type
Synthetic peptide
Immunogen
AS3MT antibody was raised against synthetic peptide AALRDAEIQKDVQ-C from the N-terminus of human AS3MT (NP_065733.2). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (92%), Orangutan (92%), Gibbon (92%), Rabbit (92%), Rat (85%), Elephant (85%), Horse (85%).
Antigen Modification
N-Terminus
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Other Notes
Small volumes of anti-AS3MT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-AS3MT antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-AS3MT antibody
ELISA (1:32000), IHC-P (3.75 ug/ml)
Immunohistochemistry (IHC) of anti-AS3MT antibody
Anti-AS3MT antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
NCBI/Uniprot data below describe general gene information for AS3MT. It may not necessarily be applicable to this product.
NCBI Accession #
NP_065733.2
[Other Products]
NCBI GenBank Nucleotide #
NM_020682.3
[Other Products]
UniProt Primary Accession #
Q9HBK9
[Other Products]
UniProt Secondary Accession #
Q0VDK3; Q0VDK4; Q5PZ02; A6NP79[Other Products]
UniProt Related Accession #
Q9HBK9[Other Products]
Molecular Weight
31,098 Da
NCBI Official Full Name
arsenite methyltransferase
NCBI Official Synonym Full Names
arsenite methyltransferase
NCBI Official Symbol
AS3MT??[Similar Products]
NCBI Official Synonym Symbols
CYT19
??[Similar Products]
NCBI Protein Information
arsenite methyltransferase; methyltransferase cyt19; methylarsonite methyltransferase; arsenic (+3 oxidation state) methyltransferase; S-adenosylmethionine:arsenic (III) methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase
UniProt Protein Name
Arsenite methyltransferase
UniProt Synonym Protein Names
Methylarsonite methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase
Protein Family
Arsenite methyltransferase
UniProt Gene Name
AS3MT??[Similar Products]
UniProt Synonym Gene Names
CYT19??[Similar Products]
UniProt Entry Name
AS3MT_HUMAN
NCBI Summary for AS3MT
AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008]
UniProt Comments for AS3MT
AS3MT: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me- AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH. Belongs to the methyltransferase superfamily.
Protein type: EC 2.1.1.137; Mitochondrial; Methyltransferase
Chromosomal Location of Human Ortholog: 10q24.32
Cellular Component: mitochondrion; cytoplasm; cytosol
Molecular Function: arsenite methyltransferase activity; methylarsonite methyltransferase activity; S-adenosylmethionine-dependent methyltransferase activity
Biological Process: methylation; arsonoacetate metabolic process; toxin metabolic process
Research Articles on AS3MT
1. AS3MT SNPs were associated with arsenic metabolism efficiency and arsenic toxicity in exposed individuals.
Precautions
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Disclaimer
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