Product Name
Amylin, Rat (Iapp), Peptide
Full Product Name
Amylin, Rat (8-37)
Product Gene Name
Iapp peptide
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 4; NC_005103.3 (240724563..240729478). Location: 4q44
3D Structure
ModBase 3D Structure for P12969
Purity/Purification
Highly Purified
~95%. Purified by HPLC.
Form/Format
Supplied as a lyophilized powder.
Sequence (linear)
Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-Arg-Ser-Ser-Asn-Asn-Leu-Gly-Pro-Val-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of Iapp peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Iapp peptide
Molecular Biology; MB-Peptides
NCBI/Uniprot data below describe general gene information for Iapp. It may not necessarily be applicable to this product.
NCBI Accession #
AAA40730.1
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UniProt Primary Accession #
P12969
[Other Products]
UniProt Related Accession #
P12969[Other Products]
Molecular Weight
10,015 Da[Similar Products]
NCBI Official Full Name
amylin
NCBI Official Synonym Full Names
islet amyloid polypeptide
NCBI Official Symbol
Iapp??[Similar Products]
NCBI Protein Information
islet amyloid polypeptide; DAP; amylin; diabetes-associated peptide
UniProt Protein Name
Islet amyloid polypeptide
UniProt Synonym Protein Names
Amylin; Diabetes-associated peptide
Protein Family
Islet amyloid polypeptide
UniProt Gene Name
Iapp??[Similar Products]
UniProt Synonym Gene Names
DAP??[Similar Products]
UniProt Entry Name
IAPP_RAT
NCBI Summary for Iapp
pancreatic islet hormone found in the pancreatic amyloid deposits [RGD, Feb 2006]
UniProt Comments for Iapp
Function: Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism
By similarity.
Subunit structure: Interacts with IDE and INS
By similarity.
Subcellular location: Secreted.
Tissue specificity: Abundant in the islets of Langerhans but is not present in the brain or seven other tissues examined.
Domain: The mature protein is largely unstructured in the absence of a cognate ligand, but contrary to the human protein, it does not easily form fibrillar aggregates. Ref.7
Sequence similarities: Belongs to the calcitonin family.
Research Articles on Iapp
1. Amylin receptors are located mostly on presynaptic glutamatergic terminals connecting to area postrema neurons not displaying hyperpolarization-activated cation current. Amylin concentrations can increase glutamate release enough to cause cell firing.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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