Product Name
Cox-1, Peptide
Full Product Name
Cox-1 Blocking Peptide
Product Gene Name
Cox-1 peptide
[Similar Products]
Cox-1 peptide (MBS843553) is used for blocking the activity of Cox-1 antibody (MBS841330)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P22437
Form/Format
50 ug (0.2 mg/ml) in phosphate buffered saline (PBS), pH 7.2, containing 0.1% BSA and 0.02% thimerosal.
Appearance: Colorless liquid
Concentration
0.2 mg/ml (lot specific)
Handling
The peptide solution should be gently mixed before use.
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Other Notes
Small volumes of Cox-1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for Cox-1 peptide
Western Blot (WB)
Application Notes for Cox-1 peptide
The peptide is used for blocking the antibody activity of active Cox-1. It usually blocks the antibody activity completely in Western blot analysis by incubating the peptide with equal volume of antibody for 30 minutes at 37 degree C
NCBI/Uniprot data below describe general gene information for Cox-1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_032995.1
[Other Products]
NCBI GenBank Nucleotide #
NM_008969.4
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UniProt Primary Accession #
P22437
[Other Products]
UniProt Related Accession #
P22437[Other Products]
Molecular Weight
69,042 Da
NCBI Official Full Name
prostaglandin G/H synthase 1
NCBI Official Synonym Full Names
prostaglandin-endoperoxide synthase 1
NCBI Official Symbol
Ptgs1??[Similar Products]
NCBI Official Synonym Symbols
COX1; Cox-1; Cox-3; PHS 1; Pghs1; PGHS-1
??[Similar Products]
NCBI Protein Information
prostaglandin G/H synthase 1
UniProt Protein Name
Prostaglandin G/H synthase 1
UniProt Synonym Protein Names
Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
UniProt Gene Name
Ptgs1??[Similar Products]
UniProt Synonym Gene Names
Cox-1; Cox1; COX-1; PGH synthase 1; PGHS-1; PHS 1??[Similar Products]
UniProt Entry Name
PGH1_MOUSE
NCBI Summary for Cox-1
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014]
UniProt Comments for Cox-1
COX-1: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Homodimer. Belongs to the prostaglandin G/H synthase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Lipid Metabolism - arachidonic acid; Oxidoreductase; EC 1.14.99.1
Cellular Component: photoreceptor outer segment; intracellular membrane-bound organelle; membrane; endoplasmic reticulum; cytoplasm; nuclear envelope; nucleus
Molecular Function: prostaglandin-endoperoxide synthase activity; peroxidase activity; dioxygenase activity; metal ion binding; heme binding; oxidoreductase activity; lipid binding
Biological Process: cyclooxygenase pathway; learning; fatty acid metabolic process; prostaglandin biosynthetic process; sensory perception of pain; memory; prostaglandin metabolic process; regulation of cell proliferation; keratinocyte differentiation; regulation of blood pressure; positive regulation of vasoconstriction; negative regulation of epinephrine secretion; positive regulation of smooth muscle contraction; response to oxidative stress; lipid metabolic process; inflammatory response; fatty acid biosynthetic process
Research Articles on Cox-1
1. In arteries from non-insulin-dependent diabetic mice, COX-1 remains a major contributor to the endothelial PGI2 synthesis that evokes vasoconstrictor activity under the pathological condition.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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