Full Product Name
Cox-1 Antibody
Product Synonym Names
Cyclooxygenase 1; PTGS1; PCOX1; COX-1; PGG/HS; PGHS1; PGHS-1; PHS1; COX1; PTGHS
Product Gene Name
anti-Cox-1 antibody
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Antibody/Peptide Pairs
Cox-1 peptide (MBS843553) is used for blocking the activity of Cox-1 antibody (MBS841330)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P22437
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity purified
Form/Format
100 ug (0.2 mg/ml) immunoaffinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% sodium azide.
Appearance: Colorless liquid
Concentration
0.2 mg/ml (lot specific)
Immunogen
Synthetic peptide corresponding to residues surrounding amino acids 586 of mouse Cox-1
Positive Control
IHC: Brain, Cortex
Handling
The antibody solution should be gently mixed before use.
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Other Notes
Small volumes of anti-Cox-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Cox-1 antibody
Background: COX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Nonsteroidal anti-inflammatory drmugs) such as aspirin. Prostaglandins (PGs) formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions thromughout the body, whereas PGs formed by COX-2 primarily mediate pain, fever, and inflammation. COX-1 is constitutively expressed, with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis.
Applications Tested/Suitable for anti-Cox-1 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC)
Application Notes for anti-Cox-1 antibody
Western blotting (1-4 ug/ml), immunoprecipitation, and Immunohistochemistry(5ug/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 70 kDa COX-1 of human, mouse and rat origins. It does not cross-react with COX-2.
NCBI/Uniprot data below describe general gene information for Cox-1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_032995.1
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NCBI GenBank Nucleotide #
NM_008969.4
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UniProt Primary Accession #
P22437
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UniProt Related Accession #
P22437[Other Products]
Molecular Weight
69,042 Da
NCBI Official Full Name
prostaglandin G/H synthase 1
NCBI Official Synonym Full Names
prostaglandin-endoperoxide synthase 1
NCBI Official Symbol
Ptgs1??[Similar Products]
NCBI Official Synonym Symbols
COX1; Cox-1; Cox-3; PHS 1; Pghs1; PGHS-1
??[Similar Products]
NCBI Protein Information
prostaglandin G/H synthase 1
UniProt Protein Name
Prostaglandin G/H synthase 1
UniProt Synonym Protein Names
Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
UniProt Gene Name
Ptgs1??[Similar Products]
UniProt Synonym Gene Names
Cox-1; Cox1; COX-1; PGH synthase 1; PGHS-1; PHS 1??[Similar Products]
UniProt Entry Name
PGH1_MOUSE
NCBI Summary for Cox-1
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014]
UniProt Comments for Cox-1
COX-1: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Homodimer. Belongs to the prostaglandin G/H synthase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.99.1; Oxidoreductase; Lipid Metabolism - arachidonic acid
Cellular Component: photoreceptor outer segment; membrane; intracellular membrane-bound organelle; endoplasmic reticulum; cytoplasm; nuclear envelope; nucleus
Molecular Function: prostaglandin-endoperoxide synthase activity; peroxidase activity; dioxygenase activity; metal ion binding; heme binding; oxidoreductase activity; lipid binding
Biological Process: cyclooxygenase pathway; learning; sensory perception of pain; fatty acid metabolic process; prostaglandin biosynthetic process; memory; prostaglandin metabolic process; regulation of cell proliferation; keratinocyte differentiation; regulation of blood pressure; positive regulation of vasoconstriction; negative regulation of epinephrine secretion; lipid metabolic process; positive regulation of smooth muscle contraction; response to oxidative stress; inflammatory response; fatty acid biosynthetic process
Research Articles on Cox-1
1. In arteries from non-insulin-dependent diabetic mice, COX-1 remains a major contributor to the endothelial PGI2 synthesis that evokes vasoconstrictor activity under the pathological condition.
Precautions
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