Full Product Name
Rabbit SLC27A4 Antibody
Product Gene Name
anti-SLC27A4 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 9; NC_000009.11 (131102839..131123749). Location: 9q34.11
3D Structure
ModBase 3D Structure for Q6P1M0
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Other Notes
Small volumes of anti-SLC27A4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SLC27A4 antibody
Immunofluorescence (IF), ELISA (EIA)
NCBI/Uniprot data below describe general gene information for SLC27A4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005085.2
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NCBI GenBank Nucleotide #
NM_005094.3
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UniProt Primary Accession #
Q6P1M0
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UniProt Secondary Accession #
O95186; A8K2F7[Other Products]
UniProt Related Accession #
Q6P1M0[Other Products]
Molecular Weight
72,064 Da
NCBI Official Full Name
long-chain fatty acid transport protein 4
NCBI Official Synonym Full Names
solute carrier family 27 (fatty acid transporter), member 4
NCBI Official Symbol
SLC27A4??[Similar Products]
NCBI Official Synonym Symbols
IPS; FATP4; ACSVL4
??[Similar Products]
NCBI Protein Information
long-chain fatty acid transport protein 4
UniProt Protein Name
Long-chain fatty acid transport protein 4
UniProt Synonym Protein Names
Solute carrier family 27 member 4
Protein Family
Long-chain fatty acid transport protein
UniProt Gene Name
SLC27A4??[Similar Products]
UniProt Synonym Gene Names
ACSVL4; FATP4; FATP-4??[Similar Products]
UniProt Entry Name
S27A4_HUMAN
NCBI Summary for SLC27A4
This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010]
UniProt Comments for SLC27A4
SLC27A4: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Defects in SLC27A4 are the cause of ichthyosis prematurity syndrome (IPS). A keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations. Belongs to the ATP-dependent AMP-binding enzyme family.
Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family; EC 6.2.1.-; Ligase
Chromosomal Location of Human Ortholog: 9q34.11
Cellular Component: endoplasmic reticulum membrane; microvillus; membrane; brush border membrane; integral to membrane; plasma membrane
Molecular Function: fatty acid transporter activity; nucleotide binding; very-long-chain-fatty-acid-CoA ligase activity; long-chain-fatty-acid-CoA ligase activity
Biological Process: long-chain fatty acid transport; skin development; transport; very-long-chain fatty acid catabolic process; long-chain fatty acid metabolic process; lipid metabolic process; medium-chain fatty acid transport; transmembrane transport; fatty acid transport; response to nutrient
Disease: Ichthyosis Prematurity Syndrome
Research Articles on SLC27A4
1. FATP4 plays crucial roles in the development and maturation of both sebaceous and meibomian glands, as well as in the formation and composition of sebum
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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