For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Affinity Purified

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-SLC27A4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This is a rabbit polyclonal antibody against SLC27A4. It was validated on Western Blot using a cell lysate as a positive control.

Target Description: SLC27A4 is involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. It appears to be the principal fatty acid transporter in small intestinal enterocytes. SLC27A4 plays a role in the formation of the epidermal barrier. It is required for fat absorption in early embryogenesis. SLC27A4 has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids.

Polyclonal; Signal Proteins; Membrane Protein; Drugs and Drug Metabolism; Developmental Biology; Membrane & Traffic;

Western Blot (WB)

WB Suggested Anti-SLC27A4 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: 293T cell lysate

WB Suggested Anti-SLC27A4 antibody Titration: 1 ug/mL
Sample Type: Human MCF7

72kDa

solute carrier family 27 member 4

long-chain fatty acid transport protein 4

Long-chain fatty acid transport protein 4

ACSVL4; FATP4; FATP-4??[Similar Products]

S27A4_HUMAN

This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010]

SLC27A4: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Defects in SLC27A4 are the cause of ichthyosis prematurity syndrome (IPS). A keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations. Belongs to the ATP-dependent AMP-binding enzyme family.

Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family; EC 6.2.1.-; Ligase

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: endoplasmic reticulum membrane; microvillus; membrane; brush border membrane; integral to membrane; plasma membrane

Molecular Function: fatty acid transporter activity; nucleotide binding; very-long-chain-fatty-acid-CoA ligase activity; long-chain-fatty-acid-CoA ligase activity

Biological Process: long-chain fatty acid transport; skin development; transport; very-long-chain fatty acid catabolic process; long-chain fatty acid metabolic process; lipid metabolic process; medium-chain fatty acid transport; transmembrane transport; fatty acid transport; response to nutrient

Disease: Ichthyosis Prematurity Syndrome

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