Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1; PTGS1; COX1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Purified Rabbit Polyclonal Antibody (Pab)

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-PTGS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.

Cancer; Cardiovascular; Cell Biology; Immunology; Neuroscience; Signal Transduction

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)

WB~~1:1000

Western blot analysis of lysate from A431 cell line,using Cox1 Antibody(MBS9211400). MBS9211400 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug.

Western blot analysis of extracts from HuvEc cells (Lane 2), using Cox1 Antibody. The lane on the left is treated with systhesized peptide.

Immunohistochemical analysis of paraffin-embedded human brain tissue using COX1 antibody.

68686

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

prostaglandin G/H synthase 1

Prostaglandin G/H synthase 1

COX1; COX-1; PGH synthase 1; PGHS-1; PHS 1??[Similar Products]

PGH1_HUMAN

This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

COX-1: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Homodimer. Belongs to the prostaglandin G/H synthase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - arachidonic acid; Oxidoreductase; EC 1.14.99.1

Chromosomal Location of Human Ortholog: 9q32-q33.3

Cellular Component: endoplasmic reticulum membrane; photoreceptor outer segment; intracellular membrane-bound organelle; cytoplasm; nucleus

Molecular Function: prostaglandin-endoperoxide synthase activity; peroxidase activity; dioxygenase activity; metal ion binding; heme binding

Biological Process: regulation of blood pressure; xenobiotic metabolic process; cyclooxygenase pathway; arachidonic acid metabolic process; response to oxidative stress; lipid metabolic process; prostaglandin biosynthetic process; inflammatory response; regulation of cell proliferation

Yokoyama C.,et al.Biochem. Biophys. Res. Commun. 165:888-894(1989).
Funk C.D.,et al.FASEB J. 5:2304-2312(1991).
Takahashi Y.,et al.Biochem. Biophys. Res. Commun. 182:433-438(1992).
Diaz A.,et al.J. Biol. Chem. 267:10816-10822(1992).
Scott B.T.,et al.Blood Coagul. Fibrinolysis 13:519-531(2002).

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