Prostaglandin G/H synthase 1; prostaglandin-endoperoxide synthase 1; COX 1 antibody; COX 3 antibody; COX-1 antibody; COX1 antibody; COX3 antibody; Cyclooxygenase 1 antibody; Cyclooxygenase 3, included antibody; Cyclooxygenase-1 antibody; Cyclooxygenase1 antibody; EC 1.14.99.1 antibody; Partial COX1 proteins, included antibody; PCOX 1 antibody; PCOX1 antibody; PGG/HS antibody; PGH synthase 1 antibody; PGH1_HUMAN antibody; PGHS 1 antibody; PGHS-1 antibody; PGHS1 antibody; PHS 1 antibody; PHS1 antibody; Prostaglandin endoperoxide synthase 1 antibody; Prostaglandin G/H synthase 1 antibody; Prostaglandin G/H synthase and cyclooxygenase antibody; Prostaglandin H Synthase 1 antibody; Prostaglandin H2 synthase 1 antibody; Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) antibody; Prostaglandin-endoperoxide synthase 1 antibody; PTGHS antibody; PTGS 1 antibody; PTGS1 antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Immunogen affinity purified.

Lyophilized

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-PTGS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Description: Rabbit IgG polyclonal antibody for Prostaglandin G/H synthase 1(PTGS1) detection. Tested with WB, IHC-P in Human, Rat.
Background: Cyclooxygenase 1(COX1), also known as Prostaglandin-endoperoxide synthase (PTGS1) or mitochondrial cytochrome c oxidase subunit 1, is the key enzyme in prostaglandin biosynthesis. The gene was approximately 40 kb long, with 11 protein-coding exons. There were 599 amino acid residues with a calculated molecular mass of approximately 68 kD. By analysis of a human/hamster somatic hybrid DNA panel, it was demonstrated that the PTGS1 gene maps to chromosome 9. Human prostaglandin endoperoxide synthase exhibited 91% amino acid identity with the sheep enzyme. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Anti-COX1 Picoband antibody, MBS176993-1.JPG
IHC(P): Human Intestinal Cancer Tissue

Anti-COX1 Picoband antibody, MBS176993-2.JPG
IHC(P): Human Lung Cancer Tissue

Anti-COX1 Picoband antibody, MBS176993-3.JPG
IHC(P): Rat Intestine Tissue

Anti-COX1 Picoband antibody, MBS176993-4.JPG
IHC(P): Human Mammary Cancer Tissue

Anti-COX1 Picoband antibody, MBS176993-5.jpg
All lanes: Anti-COX1(MBS176993) at 0.5ug/ml
Lane 1: Rat Brain Tissue Lysate at 40ug
Lane 2: HELA Whole Cell Lysate at 40ug
Lane 3: JURKAT Whole Cell Lysate at 40ug
Lane 4: K562 Whole Cell Lysate at 40ug
Lane 5: MCF-7 Whole Cell Lysate at 40ug
Lane 6: A549 Whole Cell Lysate at 40ug
Predicted bind size: 69KD
Observed bind size: 69KD

72,010 Da

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

prostaglandin G/H synthase 1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1

Prostaglandin G/H synthase 1

COX1; COX-1; PGH synthase 1; PGHS-1; PHS 1??[Similar Products]

PGH1_HUMAN

This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

COX-1: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Homodimer. Belongs to the prostaglandin G/H synthase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.99.1; Lipid Metabolism - arachidonic acid; Oxidoreductase

Chromosomal Location of Human Ortholog: 9q32-q33.3

Cellular Component: endoplasmic reticulum membrane; photoreceptor outer segment; intracellular membrane-bound organelle; cytoplasm; nucleus

Molecular Function: prostaglandin-endoperoxide synthase activity; peroxidase activity; dioxygenase activity; metal ion binding; heme binding

Biological Process: regulation of blood pressure; xenobiotic metabolic process; cyclooxygenase pathway; arachidonic acid metabolic process; response to oxidative stress; lipid metabolic process; prostaglandin biosynthetic process; inflammatory response; regulation of cell proliferation

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