Anti -SLC27A4 (Solute Carrier Family 27 (Fatty Acid Transporter), Member 4, RP11-339B21.7-002) (Azide Free)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 9; NC_000009.11 (131102839..131123749). Location: 9q34.11

Monoclonal

IgG1,k

11C783

Mouse

Recognizes human SLC27A4.

Purified
Purified

Supplied as a liquid in PBS, pH 7.2. No preservative added (Azide free).

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-SLC27A4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

FATP4 is a transmembrane protein that is involved in the uptake and metabolism of long chain fatty acids. FATP4 has acyl-CoA synthase activity and contains an AMP-binding motif. FATP4 is linked to insulin resistance and metabolic

Antibodies; Abs to Ion Channel

Western Blot (WB)

Suitable for use in Western Blot.
Dilution: Western Blot: 1:500-1:1000

26,001 Da[Similar Products]

solute carrier family 27 (fatty acid transporter), member 4

long-chain fatty acid transport protein 4; OTTHUMP00000022264

SLC27A4 protein

Q96G53_HUMAN

This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq]

SLC27A4: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Defects in SLC27A4 are the cause of ichthyosis prematurity syndrome (IPS). A keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations. Belongs to the ATP-dependent AMP-binding enzyme family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; EC 6.2.1.-; Ligase; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: endoplasmic reticulum membrane; microvillus; membrane; brush border membrane; plasma membrane; integral to membrane

Molecular Function: fatty acid transporter activity; nucleotide binding; very-long-chain-fatty-acid-CoA ligase activity; long-chain-fatty-acid-CoA ligase activity

Biological Process: long-chain fatty acid transport; skin development; very-long-chain fatty acid catabolic process; transport; lipid metabolic process; long-chain fatty acid metabolic process; medium-chain fatty acid transport; transmembrane transport; fatty acid transport; response to nutrient

Disease: Ichthyosis Prematurity Syndrome

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